Acute and subacute cardiovascular effects of synthetic cannabinoid JWH-018 in rat

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dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.contributor.authorOzhan, Onural
dc.contributor.authorErmis, Necip
dc.contributor.authorCelbis, Osman
dc.contributor.authorSamdanci, Emine
dc.contributor.authorPetekkaya, Semih
dc.contributor.authorOruc, Mucahit
dc.contributor.authorSoylu, Ozcan
dc.date.accessioned2025-05-29T02:58:03Z
dc.date.available2025-05-29T02:58:03Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurposeThis study investigates the cardiovascular effects of the synthetic cannabinoid naphthalene-1-yl-(1-pentylindole-3-yl)methanone (JWH-018) in rats. The research aims to evaluate the pharmacologic, cardiologic, biochemical, and histopathological effects of acute and subacute administration at low and high doses. The primary research question is how JWH-018 impacts heart function, blood pressure, ECG patterns, and cardiac tissue integrity.MethodsWistar albino rats were divided into five groups: control, acute low-dose (ALD, 0.5 mg/kg), acute high-dose (AHD, 5 mg/kg), subacute low-dose (SALD, 0.5 mg/kg for 14 days), and subacute high-dose (SAHD, 5 mg/kg for 14 days). Cardiovascular effects were assessed using echocardiography, hemodynamic and ECG analysis, histopathology, biochemical markers, and LC-MS/MS quantification of JWH-018 and its metabolites in heart tissue.ResultsAcute high-dose JWH-018 caused bradycardia and hypotension, while subacute high-dose increased heart rate but continued to lower blood pressure. JWH-018 induced cardiac arrhythmias, conduction blocks, and ischemic ECG changes, with prolonged QT intervals in subacute high-dose rats. Histopathological findings revealed myocardial infarction-like features, including contraction bands and ischemic damage, particularly in subacute groups. Elevated pro-BNP and triglycerides indicated cardiac stress and metabolic effects. JWH-018 and its metabolites were detected in heart tissue, primarily in high-dose groups.ConclusionsJWH-018 has significant cardiovascular risks, causing heart rate dysregulation, hypotension, arrhythmias, and ischemic damage. These effects depend on dose and duration. The study highlights the potential dangers of synthetic cannabinoids, emphasizing that they should not be considered safe alternatives to natural cannabis.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBITAK) [215S752]
dc.description.sponsorshipThis research is supported by a research grant from the Scientific and Technological Research Council of Turkiye (TUBITAK) (Project number: 215S752 belongs to Parlakpinar H.). The authors thank Leyla Sahin Buyukkorkmaz, Ismail Altin and Digdem Kurukafa for technical assistance, and Mustafa Huz for histopathological interpretation.
dc.identifier.doi10.1007/s11419-025-00720-9
dc.identifier.issn1860-8965
dc.identifier.issn1860-8973
dc.identifier.pmid40240703
dc.identifier.scopus2-s2.0-105002643797
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s11419-025-00720-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30259
dc.identifier.wosWOS:001468237900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofForensic Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectSynthetic cannabinoids
dc.subjectJWH-018
dc.subjectHeart
dc.subjectRat
dc.titleAcute and subacute cardiovascular effects of synthetic cannabinoid JWH-018 in rat
dc.typeArticle

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