Quercetin, a Powerful Antioxidant Bioflavonoid, Prevents Oxidative Damage in Different Tissues of Long-Term Diabetic Rats

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dc.contributor.authorEdremitlioglu, Mustafa
dc.contributor.authorAndic, Mehmet Fatih
dc.contributor.authorKorkut, Oguzhan
dc.date.accessioned2025-01-27T20:58:06Z
dc.date.available2025-01-27T20:58:06Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The role of oxidant damage on the development of end-organ injuries caused by diabetic rat is well known. The aim of this study is to examine the effect of quercetin, which is a strong antioxidant bioflavonoid, on oxidant damage and antioxidant capacity in various organs in the case of medium-term or long-term diabetic rat. Material and Methods: Forty-eight male Wistar rats were divided into five groups, namely, control group, diabetic group of 8-weeks, diabetic group of 16-weeks, quercetin treated diabetic group of 8-weeks, and quercetin treated diabetic group of 16-weeks. At the end of the experiment, malondialdehyde levels, superoxide dismutase, catalase, and glutathione peroxidase activities, were measured in the lung, aorta, heart, spleen, liver, and kidney tissues. Results: MDA levels were elevated in all tissues except in the lung in non-treated diabetic groups. Quercetin treatment increased the antioxidant enzyme capacities and considerably reduced oxidant damage. Conclusion: We suggest that quercetin has a protective effect on the aorta, heart, brain, liver, and kidneys from oxidant damage in the case of medium-term or long-term diabetic rat. It can be argued that quercetin is effective by increasing the antioxidant defence capacity in this process.
dc.identifier.doi10.5152/balkanmedj.2011.002
dc.identifier.endpage55
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84862086444
dc.identifier.scopusqualityQ1
dc.identifier.startpage49
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2011.002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26612
dc.identifier.volume29
dc.identifier.wosWOS:000303618400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectQuercetin
dc.subjectdiabetic rat
dc.subjectoxidative damage
dc.subjectantioxidant enzymes
dc.titleQuercetin, a Powerful Antioxidant Bioflavonoid, Prevents Oxidative Damage in Different Tissues of Long-Term Diabetic Rats
dc.typeArticle

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