Fabrication of AuNPs/PHCQE/GPE electrochemical sensor for the determination of isoniazid

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dc.contributor.authorBaycan, Fatma
dc.contributor.authorSaglikoglu, Gulsen
dc.date.accessioned2025-01-27T18:53:31Z
dc.date.available2025-01-27T18:53:31Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we have developed an electrochemical sensor based conjugated polymer to determine the compound isoniazid. Isoniazid is a drug-active substance widely used in the treatment of tuberculosis. To determine isoniazid electrochemically, 3-(5,8-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-3-9-hexyl-9H-carbazole-3-yl)quinoxalin-2-yl)-9-hexyl-9H-carbazole monomer was first electropolymerized on a graphite pencil electrode and then gold nanoparticles were doped on it. The prepared electrode showed excellent electrocatalytic activity for the oxidation of isoniazid. The electrochemical behavior of isoniazid was examined, and oxidation of isoniazid was determined by the Cyclic Voltammetry technique as a diffusion controlled. The linearity range of isoniazid was calculated 3–100 µM and the detection limit was 0.310 ?M by using differential pulse voltammetry. An electrochemical sensor was successfully applied to the determination of isoniazid in tablet dosage forms. The suggested method provides good recovery, wide linearity range and low detection limit. In addition, interference, repeatability, reproducibility and stability studies were carried out. © 2025 Elsevier B.V.
dc.identifier.doi10.1016/j.microc.2025.112662
dc.identifier.issn0026-265X
dc.identifier.scopus2-s2.0-85214702934
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.microc.2025.112662
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12739
dc.identifier.volume209
dc.identifier.wosWOS:001419771400001
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofMicrochemical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.titleFabrication of AuNPs/PHCQE/GPE electrochemical sensor for the determination of isoniazid
dc.typeArticle

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