EFFECTS OF SUBCHRONIC EXPOSURE TO PHOSALONE ON OXIDATIVE STRESS AND HISTOPATHOLOGICAL ALTERATIONS IN COMMON CARP (Cyprinus carpio, L., 1758)

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dc.authoridGurkan, Mert/0000-0001-7861-3999
dc.authoridYılmaz, Sevdan/0000-0002-4809-5809
dc.contributor.authorKaya, Hasan
dc.contributor.authorCelik, Ekrem Sanver
dc.contributor.authorGurkan, Mert
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorAkbulut, Mehmet
dc.date.accessioned2025-01-27T20:31:35Z
dc.date.available2025-01-27T20:31:35Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, possible oxidative stress, biomarkers, and histopathological alterations were investigated in common carp (Cyprinus carpio, L., 1758) that were exposed to various phosalone concentrations in vivo. Fish were exposed to 0.15, 0.3, and 0.6 mg/L phosalone concentrations in a semistatic regime for 14 d. Biomarkers, including Na+, K+-ATPase, reduced glutathione (GSH), thiobarbituric acid-reactive substances (TBARS), and histopathological changes, were determined in gills, liver, and kidney tissues of fish. Sublethal phosalone concentrations produced lipid peroxidation and impairment in the antioxidant defense system by increasing reactive oxygen species (ROS) production. While GSH increased in all groups at d 7 compared to control, GSH fell significantly at medium and high doses at d 14. Reduced GSH levels were diminished in all tissues and a significant induction in lipid peroxidation (TBARS) was observed. Na+,K+-ATPase enzyme activity was significantly inhibited especially in gills. No histopathological effects were observed in the control group. Lamellar aneurysm, lamellar fusion, hyperplasia, epithelial lifting, and hemorrhages were observed in gill tissues exposed to phosalone. Histopathological effects in the liver tissues of fish exposed to phosalone were characterized by cytoplasmic vacuolation, congestion, hypertrophy, and nuclear degeneration. Hypertrophy, tubule degeneration, mononuclear cell infiltration, and dilation of glomerular capillaries were noted in kidney tissues exposed to phosalone. The results indicate that phosalone exposure adversely affected the health of the fish, attributable to oxidative stress.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Foundation (BAP) [2010/80]
dc.description.sponsorshipThis study was partly supported by the Canakkale Onsekiz Mart University Scientific Foundation (BAP) (project 2010/80).
dc.identifier.doi10.1080/15287394.2013.823136
dc.identifier.endpage864
dc.identifier.issn1528-7394
dc.identifier.issn1087-2620
dc.identifier.issue14
dc.identifier.pmid24053362
dc.identifier.scopus2-s2.0-84885102904
dc.identifier.scopusqualityQ2
dc.identifier.startpage853
dc.identifier.urihttps://doi.org/10.1080/15287394.2013.823136
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23207
dc.identifier.volume76
dc.identifier.wosWOS:000324610800003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Toxicology and Environmental Health-Part A-Current Issues
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectFresh-Water Fish
dc.subjectAntioxidant System
dc.subjectGill
dc.subjectInhibition
dc.subjectBiomarkers
dc.subjectResponses
dc.subjectCatfish
dc.subjectKidney
dc.subjectAtpase
dc.subjectLiver
dc.titleEFFECTS OF SUBCHRONIC EXPOSURE TO PHOSALONE ON OXIDATIVE STRESS AND HISTOPATHOLOGICAL ALTERATIONS IN COMMON CARP (Cyprinus carpio, L., 1758)
dc.typeArticle

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