Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wroclaw University of Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background. Lithium is widely used in the treatment of bipolar disorders and may lead to nephrogenic diabetes insipidus (NDI), following long-term treatment. Metformin is considered the preferred initial therapy for patients with type 2 diabetes mellitus (T2D). Objectives. To investigate the protective effect of metformin on the kidney damage caused by lithium administration. Materials and methods. Using an animal model of chronic lithium-induced NDI, rats were divided into 4 groups: sham, metformin, lithium, and lithium + metformin. The effects of these treatments were examined using serum electrolytes, blood and tissue total antioxidant status, total oxidant status, the oxidative stress index, urine and blood osmolality, and tissue aquaporin-2 (AQP2) levels. Additionally, histopathological changes, including congestion, hydropic swelling, tubular necrosis, tubular atrophy, and Bowman’s capsule dilatation, were evaluated. The total histopathological score was obtained by summing the scores for each pathological finding. Results. In the lithium group, biochemical variables indicating NDI, including sodium, chloride and blood osmolality, increased, and urine osmolality decreased, compared to the sham group. With metformin treatment, the blood osmolality decreased from 328.17 mOsm/kg to 306.33 mOsm/kg, and urine osmolality increased from 349.67 mOsm/kg to 754.50 mOsm/kg (p = 0.004 and p = 0.001, respectively). Tissue AQP2 levels decreased with lithium administration but stabilized with metformin treatment. Additionally, in comparison to the lithium group, the total histopathological score in the metformin group declined from 8.0 to 2.0 (p = 0.002). Conclusions. Metformin may help protect the kidneys from lithium-induced NDI through the AQP2 regulating effect and a reduction in oxidative stress.
Açıklama
Anahtar Kelimeler
Aquaporin-2, Bipolar disorder, Lithium, Metformin, Nephrogenic diabetes insipidus
Kaynak
Advances in Clinical and Experimental Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
11
Künye
Taş, H. I., & Sancak, E. B. (2021). Protective effect of metformin on lithium-induced nephrogenic diabetes insipidus: An experimental study in rats. Advances in Clinical and Experimental Medicine, 30(11) doi:10.17219/acem/140403
