Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates

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dc.authoridSova, Matej/0000-0002-8977-3450
dc.authoridYılmaz, Sevdan/0000-0002-4809-5809
dc.contributor.authorYilmaz, S.
dc.contributor.authorSova, M.
dc.contributor.authorErgun, S.
dc.date.accessioned2025-01-27T21:03:45Z
dc.date.available2025-01-27T21:03:45Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAims Antibiotics and several other chemicals have been used to prevent fish diseases. However, this situation results in economic loss for the companies in the aquaculture industry and most importantly it pollutes the environment. Cinnamic acid is a naturally occurring aromatic acid and is considered to be safe for human consumption. Therefore, in this study, the antibacterial activity of trans-cinnamic acid and commonly used antibiotics, namely chloramphenicol, vancomycin, streptomycin and erythromycin, were tested against 32 bacteria, including fish pathogens, nonpathogenic isolates and collection strains. Methods and Results Trans-cinnamic acid was applied against the bacteria using the disc diffusion and microdilution method under in vitro conditions. Antibiotics were also tested under similar conditions against all tested bacteria using the disc diffusion method. The results show that among 32 bacterial strains trans-cinnamic acid exhibited potent inhibitory effect on the Gram-negative fish pathogen Aeromonas sobria. In addition, a moderate inhibition of trans-cinnamic acid of fish pathogens Aeromonas salmonicida, Vibrio (Listonella) anguillarum, Vibrio crassostreae and Yersinia ruckeri was also observed for trans-cinnamic acid in our study. On the contrary, the majority of nonpathogenic intestinal isolates were resistant to trans-cinnamic acid. Conclusions To the best of our knowledge, this is the first report on the antimicrobial activity of trans-cinnamic acid on 24 of the studied bacteria isolated from fish. In conclusion, trans-cinnamic acid can be used as an environmentally friendly alternative additive to prevent and control primarily A. sobria, as well as other pathogenic bacteria such as A. salmonicida, V. anguillarum, V. crassostreae and Y. ruckeri. Significance and Impact of the Study This study indicated that trans-cinnamic acid may present an environmentally friendly alternative therapeutic agent against A. sobria infections in the aquaculture industry.
dc.identifier.doi10.1111/jam.14097
dc.identifier.endpage1727
dc.identifier.issn1364-5072
dc.identifier.issn1365-2672
dc.identifier.issue6
dc.identifier.pmid30179290
dc.identifier.scopus2-s2.0-85054360198
dc.identifier.scopusqualityQ2
dc.identifier.startpage1714
dc.identifier.urihttps://doi.org/10.1111/jam.14097
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27432
dc.identifier.volume125
dc.identifier.wosWOS:000450333400012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofJournal of Applied Microbiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantimicrobial
dc.subjectfish pathogens
dc.subjectintestine
dc.subjectphenolic organic acid
dc.subjecttrans-cinnamic acid
dc.titleAntimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates
dc.typeArticle

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