4-Vinylpyridine-Based Smart Nanoparticles with N-Isopropylacrylamide, 2-Hydroxyethyl Methacrylate, Acrylic acid, and Methacrylic Acid for Potential Biomedical Applications

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridÖzay, Özgür / 0000-0001-6589-9844
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorÖzay, Özgür
dc.contributor.authorAktaş, Nahit
dc.date.accessioned2025-01-27T20:57:58Z
dc.date.available2025-01-27T20:57:58Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractStimuli-responsive (pH, temperature and magnetic field) 4-vinylpyridine (4-VP)-based nanoparticles in copolymeric formulation with core-shell morphology were synthesized using N-isopropylacrylamide (NIPAM), 2-hydroxyethyl methacrylate (HEMA), acrylic acid (AAc), and methacrylic acid (MAc) as shell-forming monomers. Keeping the 4-VP ratio constant and varying the comonomer amounts produced particles with variant shell thickness. Multi-responsive p(4-VP)-based nanoparticles were further modified by reacting with different functional groups containing bromoalkanes by quaternization. These p(4-VP)-based particles were also utilized to include composite materials by encapsulating separately prepared magnetic ferrites. To demonstrate the potential usage of the synthesized particles and their modified forms as drug delivery devices, naproxene sodium salt as an antibacterial drug was used for in vitro release studies in PBS.
dc.description.sponsorshipTurkish Academy of Science; Canakkale Onsekiz Mart University [COMU-2010/187]
dc.description.sponsorshipThis work is supported by the Turkish Academy of Science under TUBA-GEBIP 2008 program and Canakkale Onsekiz Mart University (project No: COMU-2010/187).
dc.identifier.doi10.2174/157341311795542507
dc.identifier.endpage462
dc.identifier.issn1573-4137
dc.identifier.issue3
dc.identifier.scopus2-s2.0-79956265715
dc.identifier.scopusqualityQ2
dc.identifier.startpage453
dc.identifier.urihttps://doi.org/10.2174/157341311795542507
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26572
dc.identifier.volume7
dc.identifier.wosWOS:000292187300022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Nanoscience
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSmart-nanogel
dc.subjectmulti-responsive particle
dc.subjectcore-shell particles
dc.subjectdrug delivery
dc.subjectmicrogel
dc.title4-Vinylpyridine-Based Smart Nanoparticles with N-Isopropylacrylamide, 2-Hydroxyethyl Methacrylate, Acrylic acid, and Methacrylic Acid for Potential Biomedical Applications
dc.typeArticle

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