Osteryoung square wave voltammetric determination of phenazopyridine hydrochloride in human urine and tablet dosage forms based on electrochemical reduction at carbon paste electrode

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dc.authoridDilgin, Yusuf/0000-0002-2980-6871
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.authoridTURKER, GULEN/0000-0002-7554-1544
dc.contributor.authorCitak, Meryem
dc.contributor.authorYilmaz, Selahattin
dc.contributor.authorDilgin, Yusuf
dc.contributor.authorTuerker, Guelen
dc.contributor.authorYagmur, Sultan
dc.contributor.authorErdugan, Hueseyin
dc.contributor.authorErdugan, Necla
dc.date.accessioned2025-01-27T20:43:35Z
dc.date.available2025-01-27T20:43:35Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAn electroanalytical method was developed for the direct quantitative determination of phenazopyridine hydrochloride (PAP) or in other words, pyridium, in spiked human urine and tablet dosage forms. The electrochemical reduction and determination of PAP were carried out at carbon paste electrode (CPE) in various aquaeous Solution in the pH range of 0.5-12.30 by (CV) and osteryoung square wave voltammetry (OSWV). The best results were obtained for the quantitative determination of PAP by OSWV method in 0.5 mol L-1 Sulfuric acid at about pH 0.51. The peak current and peak potential depend on pH and scan rate were studied. The diffusion controlled nature of the peak was established. This electroanalytical procedure made it possible to determine PAP in the concentration range 2.5x10(-8)-2.5x10(-6) mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.5x10(-9) and 2.5x10(-8) mol L-1 respectively. Precision and accuracy of the developed method were checked by recovery studies in spiked urine and tablet dosage forms.
dc.identifier.doi10.2174/157341207780598977
dc.identifier.endpage145
dc.identifier.issn1573-4129
dc.identifier.issue2
dc.identifier.scopus2-s2.0-34248654594
dc.identifier.scopusqualityQ3
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.2174/157341207780598977
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24281
dc.identifier.volume3
dc.identifier.wosWOS:000245774000007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Pharmaceutical Analysis
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectphenazopyridine hydrochloride
dc.subjectOSWV
dc.subjectdetermination
dc.subjectCPE
dc.subjecthuman urine
dc.subjecttablets
dc.titleOsteryoung square wave voltammetric determination of phenazopyridine hydrochloride in human urine and tablet dosage forms based on electrochemical reduction at carbon paste electrode
dc.typeReview Article

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