C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects

dc.contributor.authorErdogan, M. O.
dc.contributor.authorYildiz, S. H.
dc.contributor.authorSolak, M.
dc.contributor.authorEser, O.
dc.contributor.authorCosar, E.
dc.contributor.authorEser, B.
dc.contributor.authorKoken, R.
dc.date.accessioned2025-01-27T20:55:53Z
dc.date.available2025-01-27T20:55:53Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAssociation between neural tube defects (NTDs) and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was suspected, because the MTHFR gene codes for a key enzyme in folate metabolism. Its deficiency usually leads to significant reductions in plasma concentrations of folate, vitamin B-12 and methionine, whereas homocysteine levels are increased. We examined folate, vitamin B-12 and homocysteine serum concentrations and polymorphism of the C677T MTHFR gene in Turkish children with neural tube defects. Thirty-three children with NTDs, 26 mothers and 48 healthy individuals were studied. C677T MTHFR polymorphism was determined by melting curve analyses (LightCycler (R)). The levels of folate, vitamin B-12 and homocysteine serum concentrations in NTDs were evaluated and compared, along with information concerning alleles of the MTHFR gene. C677T allele frequencies in NTD children and their mothers were similar to those found in controls. Serum folate and vitamin B-12 concentrations were significantly higher in NTD children than that of controls. Serum homocysteine concentrations were not significantly higher in NTD children and mothers. We concluded that C677T MTHFR gene polymorphism does not affect folic acid, vitamin B-12 and homocysteine metabolism in Turkish children with NTDs. C677T polymorphism of the MTHFR gene cannot be regarded as a major risk factor for NTDs in Turkish children.
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Projects Commission [051.TIP.40]
dc.description.sponsorshipResearch supported by the Afyon Kocatepe University Scientific Research Projects Commission (#051.TIP.40).
dc.identifier.doi10.4238/vol9-2gmr816
dc.identifier.endpage1203
dc.identifier.issn1676-5680
dc.identifier.issue2
dc.identifier.pmid20589617
dc.identifier.scopus2-s2.0-77954431966
dc.identifier.scopusqualityQ4
dc.identifier.startpage1197
dc.identifier.urihttps://doi.org/10.4238/vol9-2gmr816
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26224
dc.identifier.volume9
dc.identifier.wosWOS:000280396600061
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFunpec-Editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectC677T polymorphism
dc.subjectFolate
dc.subjectHomocysteine
dc.subjectMTHFR
dc.subjectVitamin B-12
dc.titleC677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects
dc.typeArticle

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