Micronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma

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dc.contributor.authorYazici, Ibrahim
dc.contributor.authorCaglar, Ozge
dc.contributor.authorGuclu, Oguz
dc.contributor.authorCobanoglu, Hayal
dc.contributor.authorCoskun, Mahmut
dc.contributor.authorCoskun, Munevver
dc.contributor.authorKilic, Aytac
dc.date.accessioned2025-01-27T20:50:19Z
dc.date.available2025-01-27T20:50:19Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the study is to determine and compare micronucleus (MN), nucleoplasmic bridge (NPB) and nuclear bud (NBUD) frequencies in patients with laryngeal carcinoma and healthy controls. The study was conducted in the School of Medicine of Onsekiz Mart University. A total of 102 volunteers, 51 of whom had laryngeal carcinoma and 51 of whom were healthy control subjects, participated in this study. The Cytokinesis-Block Micronucleus Assay (CBMN) was applied to peripheral blood lymphocytes taken from patients and controls. We evaluated MN, NPBs and NBUDs frequencies in patients with laryngeal carcinoma and compared the results with those in the control group. The frequencies of MN, NPBs and NBUDs of patients with laryngeal carcinoma were found significantly higher than those in the control group (P = 0.01, P = 0.004, P = 0.01, respectively). MN, NPB and NBUD frequencies were also compared in the patients with and without pesticide exposure, and the means of all frequencies was higher in patients with pesticide exposure (P = 0.001, P = 0.02 respectively). The MN, NPBs and NBUDs frequencies of the patients with laryngeal cancer were significantly higher than those of the control group, and pesticide exposure might be a risk factor that increases genomic instability and risk of laryngeal cancer.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [TTU-2014-197]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit, Project number: TTU-2014-197.
dc.identifier.doi10.14639/0392-100X-N0490
dc.identifier.endpage414
dc.identifier.issn0392-100X
dc.identifier.issn1827-675X
dc.identifier.issue6
dc.identifier.pmid33558768
dc.identifier.scopus2-s2.0-85099991179
dc.identifier.scopusqualityQ2
dc.identifier.startpage410
dc.identifier.urihttps://doi.org/10.14639/0392-100X-N0490
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25466
dc.identifier.volume40
dc.identifier.wosWOS:000610372600003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPacini Editore
dc.relation.ispartofActa Otorhinolaryngologica Italica
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectmicronucleus
dc.subjectnucleoplasmic bridge
dc.subjectnuclear bud
dc.subjectlarynx cancer
dc.subjectfrequency
dc.titleMicronucleus, nucleoplasmic bridge and nuclear bud frequencies in patients with laryngeal carcinoma
dc.title.alternativeMicronucleo, ponte nucleoplasmatico e frequenze di gemme nucleari in pazienti con carcinoma laringeo
dc.typeArticle

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