Anthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro

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dc.authoridROSSELLI, Sergio/0000-0002-2448-9192
dc.authoridConforti, Filomena/0000-0001-6699-005X
dc.authoridBruno, Maurizio/0000-0003-0583-0487
dc.authoridRigano, Daniela/0000-0002-9176-8044
dc.contributor.authorConforti, Filomena
dc.contributor.authorMenichini, Federica
dc.contributor.authorFormisano, Carmen
dc.contributor.authorRigano, Daniela
dc.contributor.authorSenatore, Felice
dc.contributor.authorBruno, Maurizio
dc.contributor.authorRosselli, Sergio
dc.date.accessioned2025-01-27T20:47:31Z
dc.date.available2025-01-27T20:47:31Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAnthemis wiedemanniana is known in folk medicine for the treatment of microbial infections, cancer and also urinary and pulmonary problems. In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vulgaris. Besides that, it exhibited a high inhibitory effect on the LPS-induced nitrite production and a strong cytotoxic activity, especially against amelanotic melanoma (C32) and large lung cell carcinoma (COR-L23) cell lines.
dc.identifier.doi10.1080/14786419.2011.585988
dc.identifier.endpage1601
dc.identifier.issn1478-6419
dc.identifier.issue17
dc.identifier.pmid22124231
dc.identifier.scopus2-s2.0-84865198431
dc.identifier.scopusqualityQ1
dc.identifier.startpage1594
dc.identifier.urihttps://doi.org/10.1080/14786419.2011.585988
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24945
dc.identifier.volume26
dc.identifier.wosWOS:000307350800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnthemis wiedemanniana
dc.subjectessential oil
dc.subjectantimicrobial activity
dc.subjectinhibition of NO production
dc.subjectantiproliferative activity
dc.titleAnthemis wiedemanniana essential oil prevents LPS-induced production of NO in RAW 264.7 macrophages and exerts antiproliferative and antibacterial activities in vitro
dc.typeArticle

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