Functional Genetic Variants in Apoptosis-associated FAS and FASL Genes and Risk of Bladder Cancer in a Turkish Population

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dc.authoridOzturk, Tulin/0000-0001-6910-1131
dc.authoridergen, arzu/0000-0001-5736-8453
dc.authoridSURMEN, Saime/0000-0002-7748-0757
dc.authoridOzturk, Oguz/0000-0002-2439-9269
dc.authoridVerim, Levent/0000-0002-5295-5410
dc.authoridAkbas, Alpaslan/0000-0003-1470-5952
dc.contributor.authorVerim, Levent
dc.contributor.authorTimirci-Kahraman, Ozlem
dc.contributor.authorAkbulut, Habib
dc.contributor.authorAkbas, Alpaslan
dc.contributor.authorOzturk, Tulin
dc.contributor.authorTuran, Saime
dc.contributor.authorYaylim, Ilhan
dc.date.accessioned2025-01-27T20:41:41Z
dc.date.available2025-01-27T20:41:41Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The present study aimed to evaluate the role of functional polymorphisms of apoptosis-associated Fatty acid synthase (FAS) and fatty acid synthase ligand (FASL) genes in bladder cancer susceptibility as first presentation in a Turkish population. Patients and Methods: Genotypes of 91 patients with bladder cancer and 101 healthy controls were evaluated for the polymorphism of FAS-1377 G/A and FASL-844 T/C genes by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The frequency of the FAS-1377 G allele was significantly higher in patients with bladder cancer compared to controls (p<0.001). A significantly increased risk for developing bladder cancer was found for the group bearing a T allele for FASL-844 compared to the homozygous FASL-844 CC genotype (p=0.027). FAS-1377 GG genotype and FASL-844 T allele were found to be independently associated with an increased risk of bladder cancer. Additionally, gene gene interaction analysis revealed that the frequency of FAS-1377AA with FASL-844TC was significantly lower in patients with bladder cancer in comparison to those of controls (p<0.001). Extensive studies for gene gene interaction are still needed. Conclusion: Our study provides new evidence that FAS-1377 G and FASL-844 T alleles may be used as low-penetrant risk factors for bladder cancer development in a Turkish population.
dc.identifier.endpage402
dc.identifier.issn0258-851X
dc.identifier.issn1791-7549
dc.identifier.issue3
dc.identifier.pmid24815844
dc.identifier.scopus2-s2.0-84918561120
dc.identifier.scopusqualityQ2
dc.identifier.startpage397
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24211
dc.identifier.volume28
dc.identifier.wosWOS:000336075800018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofIn Vivo
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectbladder cancer
dc.subjectFAS
dc.subjectFAS ligand
dc.subjectpolymorphism
dc.titleFunctional Genetic Variants in Apoptosis-associated FAS and FASL Genes and Risk of Bladder Cancer in a Turkish Population
dc.typeArticle

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