Impact of a Limosilactobacillus fermentum, Quercetin, and Resveratrol Nutraceutical on Fecal Microbiota Composition and Metabolic Activity in Healthy and Hypertensive Subjects

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dc.authoridde Oliveira Melo, Nathalia Caroline/0000-0001-8255-8670
dc.authoridTrindade da Costa, Paulo Cesar/0000-0003-3273-2399
dc.authoridde Souza, Evandro/0000-0003-4927-9383
dc.contributor.authorBrasil, Jessica Maria Alves
dc.contributor.authorMelo, Nathalia Caroline de Oliveira
dc.contributor.authorSampaio, Karoliny Brito
dc.contributor.authorda Costa, Paulo Cesar Trindade
dc.contributor.authorDuman, Hatice
dc.contributor.authorKarav, Sercan
dc.contributor.authorLima, Marcos dos Santos
dc.date.accessioned2025-05-29T02:57:23Z
dc.date.available2025-05-29T02:57:23Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA promising strategy to improve the gut microbiome in hypertension is to target the gut microbiota. This study evaluated the effects of a potential nutraceutical product composed of three strains of Limosilactobacillus (L.) fermentum, quercetin, and resveratrol on the intestinal microbiome of healthy and hypertensive subjects. The nutraceutical product consisting of strains of L. fermentum 139, 263 and 296, fructooligosaccharides (200 mg), quercetin (160 mg), and resveratrol (150 mg) (LfQR) was added to the in vitro fecal fermentation process occurring for 48 h. Fecal samples of healthy and hypertensive subjects were allocated into four groups: (i) healthy controls (CTL); (ii) healthy controls with the addition of LfQR (CTL + LfQR); (iii) hypertensive (HTN) subjects; and (iv) hypertensive subjects with the addition of LfQR (HTN + LfQR). The diversity and composition of the fecal microbiota and the production of microbial metabolites were evaluated. CTL and HTN groups exhibited a distinct gut microbiota composition, as shown by the beta-diversity assessment. The addition of the potentially nutraceutical-modulated beta-diversity was similar between CTL and HTN groups, suggesting a similar gut microbiome composition after nutraceutical addition. The addition of the nutraceutical product increased the relative abundance of Enterobacteriaceae in the CTL group and that of Lachnospiraceae in the HTN group. The nutraceutical media showed higher levels of sugars (maltose, fructose, and glucose), lactic acid, ethanol, succinic acid, and acetic acid compared to the CTL and HTN media. Although the results are heterogeneous between healthy and hypertensive fermentation media, it was demonstrated that the nutraceutical formulation can modulate the intestinal microbiota and its metabolic activity.
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq); [404353/2021-5]
dc.description.sponsorshipThis research was funded by the National Council for Scientific and Technological Development (CNPq), grant number [404353/2021-5].
dc.identifier.doi10.3390/foods14060986
dc.identifier.issn2304-8158
dc.identifier.issue6
dc.identifier.pmid40231971
dc.identifier.scopus2-s2.0-105001236073
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/foods14060986
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30041
dc.identifier.volume14
dc.identifier.wosWOS:001452354200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofFoods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectbioactive compounds
dc.subjectintestinal microbiota
dc.subjecthypertension
dc.subjectprebiotic
dc.subjectprobiotic
dc.titleImpact of a Limosilactobacillus fermentum, Quercetin, and Resveratrol Nutraceutical on Fecal Microbiota Composition and Metabolic Activity in Healthy and Hypertensive Subjects
dc.typeArticle

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