Aryl benzofuran derivatives from the stem bark of Calpocalyx dinklagei attenuate inflammation

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dc.authoridTASKIN-TOK, Tugba/0000-0002-0064-8400
dc.contributor.authorKapche, Deccaux W. F. G.
dc.contributor.authorLekane, Nadege M.
dc.contributor.authorKulabas, Seda S.
dc.contributor.authorIpek, Hande
dc.contributor.authorTok, Tugba T.
dc.contributor.authorNgadjui, Bonaventure T.
dc.contributor.authorDemirtas, Ibrahim
dc.date.accessioned2025-01-27T20:47:31Z
dc.date.available2025-01-27T20:47:31Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCalpocalyx dinklagei Harms (Fabaceae) is a tropical medicinal tree, which is indigenous to Western Africa. A phytochemical study of this local plant species from its stem bark has led to the isolation of two previously undescribed aryl benzofuran derivatives, named dinklagein A and B, together with eight known compounds. Their chemical structures were elucidated by use of extensive spectroscopic methods (IR, HREI-MS and 1D and 2D NMR). Among all isolates, dinklagein A displayed remarkably potent inhibitory activity against the production of nitric oxide (NO) in the lipopolysaccharide (LPS) induced RAW264.7 macrophages. SAR and molecular docking investigations on iNOS and previously undescribed compounds (dinklagein A and B) supported experimental data. Furthermore, dinklagein A dose dependently suppressed the LPS-stimulated iNOS expression at both mRNA and protein level. It also attenuated IL-1 beta release, mRNA expressions of IL-1 beta and COX-2 at low doses. These results suggest that dinklagein A can be developed as natural, multi-target agent against several inflammatory diseases. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [P 2221]; Academy of Sciences for the Developing World (TWAS) [12-146RG/CHE/AF/AC-I-UNESCO FR 3240271356]; Canakkale Onsekiz Mart University, Scientific Research Project [FYL-2015-434]
dc.description.sponsorshipDeccaux W. F. G. Kapche is grateful to the Scientific and Technological Research Council of Turkey (TUBITAK) for 3 months maintenance grant (P 2221) and to Cankiri Karatekin University, Faculty of Science, Department of Chemistry for providing research facilities. The Academy of Sciences for the Developing World (TWAS) is acknowledged for the project grant No: 12-146RG/CHE/AF/AC-I-UNESCO FR 3240271356. Studies related with bioactivity part were partially supported by Canakkale Onsekiz Mart University, Scientific Research Project (FYL-2015-434).
dc.identifier.doi10.1016/j.phytochem.2017.05.007
dc.identifier.endpage79
dc.identifier.issn0031-9422
dc.identifier.issn1873-3700
dc.identifier.pmid28577435
dc.identifier.scopus2-s2.0-85020048235
dc.identifier.scopusqualityQ1
dc.identifier.startpage70
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2017.05.007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24940
dc.identifier.volume141
dc.identifier.wosWOS:000406725900008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPhytochemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCalpocalyx dinklagei
dc.subjectFabaceae
dc.subjectDinklagein A
dc.subjectAnti-inflammatory agent
dc.subjectMulti-potent
dc.titleAryl benzofuran derivatives from the stem bark of Calpocalyx dinklagei attenuate inflammation
dc.typeArticle

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