Thiol-disulphide homeostasis, ischemia-modified albumin, complete blood count-derived inflammatory markers and C-reactive protein from acute mania to early remission in bipolar disorder

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dc.authoridKorkmaz, Sukru Alperen/0000-0002-0684-3303
dc.authoridneselioglu, salim/0000-0002-0974-5717
dc.authoridEREL, Ozcan/0000-0002-2996-3236
dc.contributor.authorKorkmaz, Sukru Alperen
dc.contributor.authorKizgin, Sadice
dc.contributor.authorOguz, Esra Firat
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorErel, Ozcan
dc.date.accessioned2025-01-27T21:02:08Z
dc.date.available2025-01-27T21:02:08Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: There is much recent evidence that inflammation contributes to the pathophysiology of acute mania in bipolar disorder (BD). However, no study was evaluated in which the change in thiol-disulphide homeostasis, ischemia-modified albumin (IMA), complete blood count-derived inflammatory markers (CBC-IMs) and C-reactive protein (CRP) levels in bipolar patients was followed-up from acute mania to early remission. Methods: Seventy-seven bipolar patients in acute mania and ninety-one HC were enrolled. We measured levels of thiol-disulphide parameters, IMA, and CBC-IMs such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red-cell-distribution-width (RDW)-to-platelet ratio (RPR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), CRP and platelet-to-albumin ratio (PAR), after adjusting for age, gender, body-mass index (BMI) and smoking status, during acute mania to subsequent early remission. The results were compared with HC. Results: The levels or ratios of all thiol-disulphide parameters except for disulphide, IMA and CRP of bipolar patients in both acute mania and early remission were significantly different from HC, after adjusting for confounders. The NLR, SII, CRP and PAR values of bipolar patients were significantly higher in only acute mania compared to HC. Significant changes in thiol-disulphide parameters and IMA levels were not found in early remission after acute mania. Limitations: Short follow-up period and lack of drug-naive patients. Conclusions: Our results suggest that thiol-disulphide parameters, IMA level and SIRI value might be a trait biomarkers of inflammation in BD. In addition, NLR, SII and PAR values and CRP level might be a state biomarker of inflammation in bipolar patients in a manic phase.
dc.identifier.doi10.1016/j.jad.2023.07.079
dc.identifier.endpage434
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid37459969
dc.identifier.scopus2-s2.0-85165422076
dc.identifier.scopusqualityQ1
dc.identifier.startpage426
dc.identifier.urihttps://doi.org/10.1016/j.jad.2023.07.079
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27291
dc.identifier.volume339
dc.identifier.wosWOS:001096525600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSystemic immune-inflammation index
dc.subjectSystemic inflammatory response index
dc.subjectOxidative stress
dc.subjectFollow-up
dc.subjectBipolar disorder
dc.subjectThiol-disulfide
dc.titleThiol-disulphide homeostasis, ischemia-modified albumin, complete blood count-derived inflammatory markers and C-reactive protein from acute mania to early remission in bipolar disorder
dc.typeArticle

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