Antibacterial and antibiofilm activities of some plant essential oils and synergistic effects of cinnamon essential oil with vancomycin against Clostridioides difficile: in vitro study

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dc.authoridTosun Demir, Melike Nur/0000-0002-6451-7354
dc.authoridTAYLAN YALCIN, Gizem/0000-0003-2146-8254
dc.contributor.authorTosun, M. N.
dc.contributor.authorTaylan, G.
dc.contributor.authorZorba, N. N. Demirel
dc.date.accessioned2025-01-27T20:14:16Z
dc.date.available2025-01-27T20:14:16Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe detection of resistant strains of Clostridioides difficile against existing antibiotics and the side effects led to the investigation of alternative agents. Inhibition zones of various essential oils to four strains of C.difficile and other Clostridium species ranged from 8 center dot 32 to 44 center dot 18 mm. The highest zone was observed in cinnamon and tea tree essential oils. and The MIC values varied between 0 center dot 39-25 (%, v/v). The main components were cinnamaldehyde (85 center dot 64%) in cinnamon essential oil, 4-terpineol (83 center dot 6%) was determined in tea tree essential oil. Additive effects were found between cinnamon essential oil and vancomycin and between cinnamon and tea tree essential oils, and the FICI values were 0 center dot 512 and 0 center dot 517, respectively. Both cinnamon and tea tree essential oils showed antibiofilm activities against all tested C. difficile strains at all tested concentrations. Essential oils may be used as a supplement in addition to treatment in the control of C. difficile-related diseases.
dc.description.sponsorshipCouncil of Higher Education [100/2000]
dc.description.sponsorshipMelike Nur Tosun and Gizem Taylan were supported by the Council of Higher Education 100/2000 PhD scholarship. We are also grateful to Prof. Dr Serkan Selli and Lect.Onur Sevindik for their support in determining the volatile oil profile of essential oils.
dc.identifier.doi10.1111/lam.13747
dc.identifier.endpage606
dc.identifier.issn0266-8254
dc.identifier.issn1472-765X
dc.identifier.issue3
dc.identifier.pmid35611552
dc.identifier.scopus2-s2.0-85131632859
dc.identifier.scopusqualityQ3
dc.identifier.startpage598
dc.identifier.urihttps://doi.org/10.1111/lam.13747
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21023
dc.identifier.volume75
dc.identifier.wosWOS:000806102300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofLetters in Applied Microbiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbiofilm
dc.subjectcinnamon
dc.subjectClostridioides difficile
dc.subjectessential oils
dc.subjecttea tree
dc.subjectvancomycin
dc.titleAntibacterial and antibiofilm activities of some plant essential oils and synergistic effects of cinnamon essential oil with vancomycin against Clostridioides difficile: in vitro study
dc.typeArticle

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