The effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study

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dc.contributor.authorCikman, Oztekin
dc.contributor.authorTas, Sukru
dc.contributor.authorOzkan, Omer Faruk
dc.contributor.authorErcan, Umut
dc.contributor.authorTurkon, Hakan
dc.contributor.authorKilic, Nihal
dc.contributor.authorAkgun, Yilmaz
dc.date.accessioned2026-02-03T12:00:24Z
dc.date.available2026-02-03T12:00:24Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground This study aimed to evaluate the effect of tannic acid on colonic anastomosis in a sepsis model induced by cecal abrasion.Materials and methods Thirty Sprague-Dawley rats were used. The animals were randomly divided into three groups of ten: Group 1 (n:10): Colonic anastomosis + 0.9% isotonic NaCl. Group 2 (n:10): Cecal ligation and puncture + Colonic anastomosis + 0.9% isotonic NaCl. Group 3 (n:10): Cecal ligation and puncture + Colonic anastomosis + Tannic Acid group. The rats were sacrificed on the fifth postoperative day, and the resected colon segments, bursting pressure, hydroxyproline levels, and histopathologic features of the anastomosis were evaluated.Results The bursting pressure value was statistically significantly higher in Group 3, where tannic acid was administered (p < 0.05). Group 2 and Group 3, in which peritonitis was induced, had moderate levels of fibroblastic activity, inflammatory cell infiltration, neovascularisation, and collagen; whereas, they were higher in Group 1. Although the inflammation value dropped in Group 3 compared to Groups 1 and 2, there was no statistical difference in Group 2. The hydroxyproline values were 2.046 +/- 1.1411 mcg/gr and 5.9730 +/- 4.35900 mcg/gr tissues, respectively, in Groups 2 and 3, where septic conditions prevailed, and a statistically significant difference was found (p < 0.05).Conclusion This experimental study revealed that the use of tannic acid during anastomosis has a positive effect on wound healing, acting through higher colonic anastomotic bursting pressures and higher tissue hydroxyproline levels.
dc.identifier.doi10.1371/journal.pone.0339175
dc.identifier.issn1932-6203
dc.identifier.issue12
dc.identifier.pmid41452820
dc.identifier.scopus2-s2.0-105026115846
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0339175
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34602
dc.identifier.volume20
dc.identifier.wosWOS:001649799800034
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.titleThe effect of Tannic acid on colonic anastomosis in abdominal sepsis: An experimental study
dc.typeArticle

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