Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.contributor.authorAghatabay, Naz Mohammed
dc.contributor.authorMahmiani, Yaghub
dc.contributor.authorCevik, Hueseyin
dc.contributor.authorDulger, Basaran
dc.date.accessioned2025-01-27T20:41:41Z
dc.date.available2025-01-27T20:41:41Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMixed aza-oxo-thia macrocyclic ligands 1,3,5,11,13,15-hexaaza-6,10,16,20-tetraoxo-8,18-dithia-2,3,4:12,13,14-dipyridine cyclocosane (L-1); 1,3,5,12,14,16-hexeaza-6,11,17,22-tetraoxo-8,9,19,20-tetrathia-2,3,4:13,14,15-dipyridine cyclodocosane (L-2); 1,3,5,13,15,17-hexaaza-6,12,18,24-tetraoxo-9,21-dithia-2,3,4:14,15,16-dipyfidine cyclotetracosane (L-3) and 1,3,5,14,16,18-hexaaza-6,13,19,26-tetraoxo-9,10,22,23-tetrathia2,3,4:15,16,17-dipyridine cyclohexacosane (L-4) were synthesised. The structural features of the ligands have been studied by elemental analyses, Raman, IR, H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the ligands were evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against nine bacteria. The obtained results from disk diffusion method were assessed in side-by-side comparison with those of penicillin G, ampicillin, cefotaxime, vancomycin, ofloxacin, and tetracycline well known antibacterial agents. The results from dilution procedure were compared with gentamycin as antibacterial and nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, and Hanseniaspora guilliermondii, and the results are referenced with nystatin, Ketoconazole, and clotrimazole, commercial antifungal agents. In most cases, the compounds show broad-spectrum (Gram(+) and Gram(-) bacteria) activities that were more active or equipotent to the antibiotic and antifungal agents in the comparison tests. (C) 2008 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipFatih University Scientific Research Centre [P5002064-5, P50020702]
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre for their financial support under projects (P5002064-5 and P50020702).
dc.identifier.doi10.1016/j.ejmech.2008.02.038
dc.identifier.endpage372
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue1
dc.identifier.pmid18417256
dc.identifier.scopus2-s2.0-57949084029
dc.identifier.scopusqualityQ1
dc.identifier.startpage365
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2008.02.038
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24209
dc.identifier.volume44
dc.identifier.wosWOS:000262693700039
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBroad-spectrum
dc.subjectClotrimazole
dc.subjectDisk diffusion
dc.subjectNystatin
dc.subjectRaman
dc.titleSynthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds
dc.typeArticle

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