Melanoma Inhibition by Anthocyanins Is Associated with the Reduction of Oxidative Stress Biomarkers and Changes in Mitochondrial Membrane Potential

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dc.authoridLeopold, Loredana Florina/0000-0002-8084-1998
dc.authoridDiaconeasa, Zorita/0000-0002-5325-3859
dc.authoridSocaciu, Carmen/0000-0002-7352-5057
dc.authoridRUGINA, Dumitrita Olivia/0000-0003-4881-3273
dc.contributor.authorDiaconeasa, Zorita
dc.contributor.authorAyvaz, Huseyin
dc.contributor.authorRugina, Dumitrita
dc.contributor.authorLeopold, Loredana
dc.contributor.authorStanila, Andreea
dc.contributor.authorSocaciu, Carmen
dc.contributor.authorTabaran, Flaviu
dc.date.accessioned2025-01-27T20:14:16Z
dc.date.available2025-01-27T20:14:16Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAnthocyanins are water soluble pigments which have been proved to exhibit health benefits. Several studies have investigated their effects on several types of cancer, but little attention has been given to melanoma. The phytochemical content of nine different berry samples was assessed by liquid chromatography followed by electrospray ionization mass spectrometry (LC-ESI+-MS). Twenty-six anthocyanins were identified, after a previous C-18 Sep-pak clean-up procedure. Chokeberry and red grape anthocyanins rich extracts (C-ARE and RG-ARE) were selected to be tested on normal and melanoma cell lines, due to their different chemical pattern. C-ARE composition consists of cyanidin aglycone glycosylated with different sugars; while RG-ARE contains glucosylated derivatives of five different aglycones. Both C-ARE and RG-ARE anthocyanins reduced proliferation, increased oxidative stress biomarkers and diminished mitochondrial membrane potential in melanoma cells, having no negative influence on normal cells. A synergistic response may be attributed to the five different aglycones present in RG-ARE, which proved to exert greater effects on melanoma cells than the mixture of cyanidin derivatives with different sugars (C-ARE). In conclusion, C-ARE and RG-ARE anthocyanins may inhibit melanoma cell proliferation and increase the level of oxidative stress, with opposite effect on normal cells. Therefore, anthocyanins might be recommended as active ingredients for cosmetic and nutraceutical industry.
dc.description.sponsorshipUEFISCDI project [PN-II-RU-TE-2014-4-0944, 16/01.10.2015]
dc.description.sponsorshipThis paper was supported by UEFISCDI project number PN-II-RU-TE-2014-4-0944, 16/01.10.2015. The authors are grateful to biologist Raluca Ghiman for performing the graphical abstract.
dc.identifier.doi10.1007/s11130-017-0638-x
dc.identifier.endpage410
dc.identifier.issn0921-9668
dc.identifier.issn1573-9104
dc.identifier.issue4
dc.identifier.pmid29129015
dc.identifier.scopus2-s2.0-85033453219
dc.identifier.scopusqualityQ1
dc.identifier.startpage404
dc.identifier.urihttps://doi.org/10.1007/s11130-017-0638-x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21026
dc.identifier.volume72
dc.identifier.wosWOS:000417183700011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPlant Foods For Human Nutrition
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAnthocyanins
dc.subjectProliferation
dc.subjectMDA
dc.subjectLDH
dc.subjectMitotracker
dc.subjectMelanoma
dc.titleMelanoma Inhibition by Anthocyanins Is Associated with the Reduction of Oxidative Stress Biomarkers and Changes in Mitochondrial Membrane Potential
dc.typeArticle

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