Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Related to Inflammation Markers and Anti-CCP in Rheumatoid Arthritis

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dc.contributor.authorGokmen, F.
dc.contributor.authorAkbal, A.
dc.contributor.authorResorlu, H.
dc.contributor.authorBinnetoglu, E.
dc.contributor.authorCevizci, S.
dc.contributor.authorGokmen, E.
dc.contributor.authorKose, M. M.
dc.date.accessioned2025-01-27T20:25:03Z
dc.date.available2025-01-27T20:25:03Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Various thrombocyte markers and white blood cell levels and their subtypes have recently been investigated in association with infl ammation. The purpose of this study was to determine the correlation of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) with disease activation and clinical parameters in rheumatoid arthritis (RA) patients. Methods: 84 RA patients and 60 healthy controls were included. Platelet, MPV, white cell, neutrophil and lymphocyte levels in full blood counts were investigated, and NLR was calculated. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), disease activation score (DAS 28) and a health assessment questionnaire (HAQ) were used in the evaluation of RA. Results: In the present study a total of 144 patients was enrolled, 84 with RA and 60 healthy individuals. 75.2 % (n = 108) were women and 24.8 % (n = 36) were men. The patients with RA had lower MPV than control individuals (MPV; 8.52 +/- 1.15 fL and 8.92 +/- 0.87 fL, respectively) and CRP (r: -0.234, p = 0.005). RA patients' mean NLR was signifi cantly higher than that of the control group (2.74 +/- 1.74 and 1.80 +/- 0.78, respectively; p < 0.001). Furthermore, anti-CCP positive patients had higher NLR than anti-CCP negative patients (NLR; 2.51 +/- 1.92 and 1.95 +/- 1.22, p = 0.019 respectively). NLR was positively correlated with ESR (r = 0.190, p = 0.023), CRP (r = 0.230, p = 0.035) and anti-CCP (r = 0.300, p = 0.005). Conclusion: In conclusion, MPV and NLR together with acute phase reactants can be a useful index for showing infl ammation in RA patients.
dc.identifier.doi10.1055/s-0034-1374605
dc.identifier.endpage491
dc.identifier.issn0341-051X
dc.identifier.issn1438-9940
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84903665899
dc.identifier.scopusqualityQ4
dc.identifier.startpage488
dc.identifier.urihttps://doi.org/10.1055/s-0034-1374605
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22422
dc.identifier.volume41
dc.identifier.wosWOS:000391990300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofAktuelle Rheumatologie
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectrheumatoid arthritis
dc.subjectmean platelet volume
dc.subjectneutrophil-to-lymphocyte ratio
dc.subjectinflammation
dc.titleMean Platelet Volume and Neutrophil Lymphocyte Ratio as Related to Inflammation Markers and Anti-CCP in Rheumatoid Arthritis
dc.title.alternativeMittleres Thrombozytenvolumen und Neutrophilen-Lymphozyten-Ratio in Bezug zu Entzündungsmarkern und Anti-CCP bei rheumatoider Arthritis
dc.typeArticle

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