Calibration and performance of synchronous SIM/scan mode for simultaneous targeted and discovery (non-targeted) analysis of exhaled breath samples from firefighters

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dc.authoridMentese, Sibel/0000-0002-0395-3603
dc.contributor.authorWallace, M. Ariel Geer
dc.contributor.authorPleil, Joachim D.
dc.contributor.authorMentese, Sibel
dc.contributor.authorOliver, Karen D.
dc.contributor.authorWhitaker, Donald A.
dc.contributor.authorFent, Kenneth W.
dc.date.accessioned2025-01-27T20:31:47Z
dc.date.available2025-01-27T20:31:47Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTraditionally, gas chromatography-mass spectrometry (GC/MS) analysis has used a targeted approach called selected ion monitoring (SIM) to quantify specific compounds that may have adverse health effects. Dueto method limitations and the constraints of preparing duplicate samples, the information that could be obtained from separately collecting the full scan chromatogram of the sample has often been sacrificed. However, the hybrid technique called synchronous SIM/scan mode alternates between the two acquisition modes, maintaining the accuracy and sensitivity of SIM for targeted analysis while also providing the full scan chromatogram for discovery of non-target compounds. This technology was assessed using calibration data and real-world breath samples from a joint EPA/NIOSH collaboration that investigated the safety of firefighters' protective gear during controlled structure burns. Collecting field samples is costly and must be performed strategically to ensure that time points and replicates are accurate and representative of the intended population. This is difficult to accomplish with firefighters who are working under volatile conditions. The synchronous SIM/scan method decreases the number of field samples that need to be collected by half and reduces error in trying to recreate time points since a breath sample from a single sorbent tube can be used to collect both the SIM and scan data simultaneously. As a practical demonstration of the method, we investigate thirty-six firefighter breath samples, document organic compounds of interest, and identify additional non-target compounds. Published by Elsevier B.V.
dc.description.sponsorshipCDC Foundation; U.S. Department of Homeland Security [EMW-2013-FP-00766]
dc.description.sponsorshipThe authors are appreciative for the participation of the volunteer subjects who provided breath samples for this method development and evaluation. Participants were compensated up to $599 to participate in this study. This study was approved by the NIOSH and University of Illinois Institutional Review Boards. This study was funded by the U.S. Department of Homeland Security, Assistance to Firefighters Grant (EMW-2013-FP-00766) and also made possible through a partnership with the CDC Foundation. The authors also acknowledge Lee Marotta from Perkin Elmer for technical assistance with the PAH method development and John Michael Marquardt from Perkin Elmer for instrument support. This research has been subjected to EPA review and approved for publication. The findings and conclusions in this paper are those of the authors and do not necessarily represent the views of NIOSH. Mention of trade names and commercial products does not constitute endorsement or recommendation for use.
dc.identifier.doi10.1016/j.chroma.2017.07.082
dc.identifier.endpage124
dc.identifier.issn0021-9673
dc.identifier.issn1873-3778
dc.identifier.pmid28838652
dc.identifier.scopus2-s2.0-85028013941
dc.identifier.scopusqualityQ1
dc.identifier.startpage114
dc.identifier.urihttps://doi.org/10.1016/j.chroma.2017.07.082
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23266
dc.identifier.volume1516
dc.identifier.wosWOS:000411542600012
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Chromatography A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSelected ion monitoring/scan (SIM/scan)
dc.subjectGas chromatography-mass spectrometry (GC/MS)
dc.subjectAutomated thermal desorption (ATD)
dc.subjectVolatile organic compound (VOC)
dc.subjectPolyaromatic hydrocarbon (PAH)
dc.subjectBreath research
dc.titleCalibration and performance of synchronous SIM/scan mode for simultaneous targeted and discovery (non-targeted) analysis of exhaled breath samples from firefighters
dc.typeArticle

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