The association of oxidative stress with serum irisin and betatrophin in pregnant women with gestational diabetes mellitus

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dc.contributor.authorBeyazit, Fatma
dc.contributor.authorKaracaer, Kubra Ozkan
dc.contributor.authorTurkon, Hakan
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground. Irisin and betatrophin are polypeptide hormones implicated in glucose metabolism and insulin resistance (IR). Gestational diabetes mellitus (GDM) is accompanied by oxidative stress (OS) and the association between circulating irisin and betatrophin levels and GDM is controversial. The present study aimed to investigate the association of second-trimester irisin, betatrophin concentrations and their correlations between serum OS markers in GDM patients. Methods. The study included 45 GDM patients and 45-age matched pregnant women as controls. Serum fasting glucose, HOMA-IR, ischemia modified albumin (IMA), total oxidative stress (TOS), total antioxidant status (TAS), oxidative stress index (OSI), irisin and betatrophin were measured. Results. Serum irisin levels were decreased and TOS and OSI levels were found to be increased in the patient group. No significant difference was found with respect to serum betatrophin and IMA levels between study groups. A correlation analysis revealed no correlation between serum irisin and other assessed variables. Conclusions. Gestational diabetes mellitus is an OS condition in addition to being a metabolic disease. Although not correlated with OS, irisin but not betatrophin may be a useful biomarker to predict GDM.
dc.identifier.doi10.5603/DK.2020.0039
dc.identifier.endpage334
dc.identifier.issn2450-8187
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85096438476
dc.identifier.scopusqualityQ4
dc.identifier.startpage328
dc.identifier.urihttps://doi.org/10.5603/DK.2020.0039
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23986
dc.identifier.volume9
dc.identifier.wosWOS:000590979800009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofClinical Diabetology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectirisin
dc.subjectbetatrophin
dc.subjectoxidative stress
dc.subjectgestational diabetes mellitus
dc.titleThe association of oxidative stress with serum irisin and betatrophin in pregnant women with gestational diabetes mellitus
dc.typeArticle

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