Half-Sandwich Ru(II) Complexes Bearing 2-(2¢-quinoly)benzimidazoles with Anticancer Activity

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dc.contributor.authorErdem, Ahmet
dc.contributor.authorMutlu, Dogukan
dc.contributor.authorKilincarslan, Rafet
dc.contributor.authorDayan, Osman
dc.contributor.authorArslan, Sevki
dc.date.accessioned2025-01-27T18:59:19Z
dc.date.available2025-01-27T18:59:19Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this article, cytotoxic and apoptotic properties of previously synthesized and characterized four different half?sandwich ruthenium (II) complexes (C1-C4) with 2-(2¢-quinoly) benzimidazole frameworks (L1-L5) were described. These Ru (II) complexes (C1-C4) had strong cytotoxic activity towards the human glioblastoma (U373) cancer cell line with low toxicity to the non-cancerous human embryonic kidney (HEK293) cell line. Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2. Our results indicate that ruthenium (II) complexes with 2-(2¢-quinoly) benzimidazole frameworks, especially C1 and C4, had a higher cytotoxic and apoptotic activity in human glioblastoma cells, and they should be further evaluated in detail for its anticancer properties as a new therapeutical strategy for glioblastoma. © 2024 by the authors.
dc.identifier.doi10.33263/BRIAC144.082
dc.identifier.issn2069-5837
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85204957010
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.33263/BRIAC144.082
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13225
dc.identifier.volume14
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAMG Transcend Association
dc.relation.ispartofBiointerface Research in Applied Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subject2-(2¢-quinoly)benzimidazole; anticancer; glioblastoma; half-sandwich Ru(II); piano-stool complex
dc.titleHalf-Sandwich Ru(II) Complexes Bearing 2-(2¢-quinoly)benzimidazoles with Anticancer Activity
dc.typeArticle

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