Half-Sandwich Ru(II) Complexes Bearing 2-(2¢-quinoly)benzimidazoles with Anticancer Activity
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
AMG Transcend Association
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this article, cytotoxic and apoptotic properties of previously synthesized and characterized four different half?sandwich ruthenium (II) complexes (C1-C4) with 2-(2¢-quinoly) benzimidazole frameworks (L1-L5) were described. These Ru (II) complexes (C1-C4) had strong cytotoxic activity towards the human glioblastoma (U373) cancer cell line with low toxicity to the non-cancerous human embryonic kidney (HEK293) cell line. Mechanistic studies revealed that all complexes caused apoptosis induction by activating caspases with upregulation of Bax and downregulation of Bcl-2. Our results indicate that ruthenium (II) complexes with 2-(2¢-quinoly) benzimidazole frameworks, especially C1 and C4, had a higher cytotoxic and apoptotic activity in human glioblastoma cells, and they should be further evaluated in detail for its anticancer properties as a new therapeutical strategy for glioblastoma. © 2024 by the authors.
Açıklama
Anahtar Kelimeler
2-(2¢-quinoly)benzimidazole; anticancer; glioblastoma; half-sandwich Ru(II); piano-stool complex
Kaynak
Biointerface Research in Applied Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
14
Sayı
4
