Epicardial adipose tissue thickness, flow-mediated dilatation of the brachial artery, and carotid intima-media thickness Associations in rheumatoid arthritis patients

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dc.contributor.authorTemiz, A.
dc.contributor.authorGokmen, F.
dc.contributor.authorGazi, E.
dc.contributor.authorAkbal, A.
dc.contributor.authorBarutcu, A.
dc.contributor.authorBekler, A.
dc.contributor.authorAltun, B.
dc.date.accessioned2025-01-27T21:01:35Z
dc.date.available2025-01-27T21:01:35Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim. The purpose of this work was to evaluate epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), and flow-mediated dilatation (FMD) of the brachial artery in rheumatoid arthritis (RA) patients using ultrasonographic methods. Interrelationships between these three parameters in RA patients were also investigated. Methods. EAT thickness, CIMT, and FMD were measured by ultrasonography. We measured the disease activity score (DAS28), health assessment questionnaire (HAQ) score, and C-reactive protein (CRP) levels. Spearman or Pearson correlation analysis was used to evaluate the association between clinical findings, CIMT, FMD, and EAT. Results. A total of 90 RA patients [ 19 men, mean age 54 years (range 21-76 years)] and 59 age-and gender-matched control subjects [ 17 men, mean age 54 years (range 2680 years)] were included in the study. Patients with RA had a mean 4.34 DAS28 points (range 0-40 points) and the mean duration of the disease was 77.1 months (range 1-360 months). We found that RA patients had thicker EAT (7.7 +/- 1.7 mm vs 6.2 +/- 1.8 mm, p<0.001), increased CIMT [ 0.9 (0.5-1.2) mm vs 0.6 (0.4-0.9) mm, p<0.001], and decreased FMD values [ 5.7% (-23.5 to 20%) vs. 8.5% (-4.7 to 22.2%), p=0.028] when compared to control subjects. CRP levels were significantly higher in the RA group [ 0.81 (range 0.1-13.5) vs 0.22 (range 0.05-12), p<0.001]. EAT thickness was negatively correlated with FMD (r=-0.26, p<0.001) and positively correlated with CIMT values (r=0.52, p<0.001). CIMT also negatively correlated with FMD (r=-0.29, p<0.001). Conclusion. EAT can be simply measured by echocardiography and correlated with FMD and CIMT. It can be used as a first-line measurement for estimating burden of atherosclerosis in RA patients.
dc.identifier.doi10.1007/s00059-014-4140-z
dc.identifier.endpage224
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.pmid25139185
dc.identifier.scopus2-s2.0-84940615006
dc.identifier.scopusqualityQ3
dc.identifier.startpage217
dc.identifier.urihttps://doi.org/10.1007/s00059-014-4140-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27110
dc.identifier.volume40
dc.identifier.wosWOS:000362565500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.ispartofHerz
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectUltrasonography
dc.subjectDisease activity score
dc.subjectAutoimmune diseases
dc.subjectCardiovascular diseases
dc.subjectMortality
dc.titleEpicardial adipose tissue thickness, flow-mediated dilatation of the brachial artery, and carotid intima-media thickness Associations in rheumatoid arthritis patients
dc.typeArticle

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