Endothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction

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dc.authoridKURT, HASAN ANIL/0000-0001-7292-2248
dc.contributor.authorKurt, Hasan Anil
dc.contributor.authorDemirci, Emrah
dc.contributor.authorAlan, Cabir
dc.date.accessioned2025-01-27T20:47:32Z
dc.date.available2025-01-27T20:47:32Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we aimed to determine endothelial dysfunction and ischemia-modified albumin (IMA) levels in patients diagnosed with erectile dysfunction (ED) and to examine the relationship between these and diabetes disease. 86 male patients (46 patients with diabetes, age: 51.5 +/- 9.2 and 40 patients with nondiabetes (control group), age: 54.78 +/- 12.2) were included in the study. IMA, a new indicator of tissue ischemia and oxidative stress, was checked. Superoxide dismutase (SOD) activity, another oxidative stress indicator, was examined. Endothelin-1 (ET-1), one of the parameters of endothelial dysfunction, was measured. Additionally, endothelial function was evaluated with flow-mediated vasodilatation (FMD). Student's t-test was used for statistical evaluation. p values less than 0.05 were considered statistically significant. SOD activity was significantly lower in the diabetic group than in the control group, and ET-1 was significantly higher (p < 0.001). IMA was found to be significantly higher in the diabetic group than the control group (p < 0.001). FMD was significantly lower in diabetic group compared to the control group (p < 0.002). According to our findings, the co-occurrence of erectile dysfunction and diabetes demonstrates a complex condition that includes endothelial dysfunction, oxidative stress, and tissue ischemia. When the correlation of indicators, which are markers, was examined, the severity of the co-occurrence of diabetes and erectile dysfunction was again demonstrated.
dc.identifier.doi10.1155/2022/3661822
dc.identifier.issn0278-0240
dc.identifier.issn1875-8630
dc.identifier.pmid35585936
dc.identifier.scopus2-s2.0-85130218996
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1155/2022/3661822
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24948
dc.identifier.volume2022
dc.identifier.wosWOS:000802786100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofDisease Markers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectNitric-Oxide
dc.subjectVascular Endothelin
dc.subjectAssociation
dc.subjectType-2
dc.subjectStress
dc.subjectHyperglycemia
dc.subjectVasodilation
dc.subjectPathogenesis
dc.subjectMechanisms
dc.subjectMellitus
dc.titleEndothelial Dysfunction and Ischemia-Modified Albumin Levels in Males with Diabetic and Nondiabetic Erectile Dysfunction
dc.typeArticle

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