Epidemiology and Outcomes of Neonatal Meningitis Results of the Turkish Neo-Meningitis Nationwide Study

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dc.authoridArayıcı, Sema / 0000-0002-5389-1834
dc.contributor.authorÖncel, Mehmet Yekta
dc.contributor.authorÇizmeci, Mehmet N.
dc.contributor.authorKaradağ-Öncel, Eda
dc.contributor.authorElvan-Tuz, Ayşegül
dc.contributor.authorCanpolat, Fuat Emre
dc.contributor.authorAkın, Mustafa Ali
dc.contributor.authorUslu, Sinan
dc.contributor.authorArayıcı, Sema (Collaborator)
dc.date.accessioned2025-01-27T18:56:01Z
dc.date.available2025-01-27T18:56:01Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To investigate the incidence and etiology of neonatal meningitis and to assess the associated risk factors, complications and outcomes in a nationwide multicenter retrospective descriptive study. Method: Twenty-seven centers from 7 geographical regions participated in the study. Newborns with a positive cerebrospinal fluid culture and/or cerebrospinal fluid polymerase chain reaction were included in the study. Demographic characteristics, clinical, laboratory and neuroimaging findings and mortality characteristics were analyzed. Results: A total of 634 confirmed cases of neonatal meningitis were included in the final analysis. The incidence was 2.51 per 1000 intensive care unit hospitalizations and mortality was observed in 149 (23.5%). Gram-positive bacteria were the predominant pathogens (54.5%), with coagulase-negative Staphylococci accounting for 45.3% of the cases, followed by Gram-negative organisms (37.3%). Viral and fungal organisms were isolated in 3.2% and 1.7% of the infants, respectively. Gram-negative culture growth was more common in infants who died (51% vs. 34.6%; P < 0.001). In the multivariable model, the odds of mortality was higher in those with respiratory distress requiring invasive ventilatory support [odds ratio (OR): 10.3; 95% confidence interval (CI): 4.9–21.7; P < 0.01], hypotension requiring inotropes (OR: 4.4; 95% CI: 2.7–7.1; P < 0.001), low birth weight status (OR: 2.5; 95% CI: 1.4–4.6; P = 0.002), lack of exposure to antenatal steroids (OR: 2.4; 95% CI: 1.3–4.4; P = 0.005) and the presence of concomitant sepsis (OR: 1.9; 95% CI: 1.1–3.2; P = 0.017). Conclusions: In this nationwide study, neonatal meningitis was found to be associated with high mortality. Coagulase-negative Staphylococci was the most common causative microorganism followed by Gram-negative bacteria. Severe clinical presentation with invasive mechanical ventilation and inotrope requirement, as well as concomitant sepsis, low birth weight status and lack of exposure to antenatal steroids, were found to be independent risk factors for mortality.
dc.identifier.doi10.1097/INF.0000000000004197
dc.identifier.endpage370
dc.identifier.issn0891-3668
dc.identifier.issue4
dc.identifier.pmid38134373
dc.identifier.scopus2-s2.0-85187208247
dc.identifier.scopusqualityQ1
dc.identifier.startpage365
dc.identifier.urihttps://doi.org/10.1097/INF.0000000000004197
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12823
dc.identifier.volume43
dc.identifier.wosWOS:001235391600027
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofPediatric Infectious Disease Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectepidemiology
dc.subjectmeningitis
dc.subjectmortality
dc.subjectnewborn
dc.subjectoutcomes
dc.titleEpidemiology and Outcomes of Neonatal Meningitis Results of the Turkish Neo-Meningitis Nationwide Study
dc.typeArticle

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