The neuroprotective effect of fish n-3 fatty acids in the hippocampus of diabetic rats

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dc.authoridOzen, Oguz Aslan/0000-0003-2521-0031
dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.authoridyagmurca, murat/0000-0001-9774-8151
dc.contributor.authorCosar, Murat
dc.contributor.authorSongur, Ahmet
dc.contributor.authorSahin, Onder
dc.contributor.authorUz, Efkan
dc.contributor.authorYilmaz, Ramazan
dc.contributor.authorYagmurca, Murat
dc.contributor.authorOzen, Oguz Aslan
dc.date.accessioned2025-01-27T20:43:34Z
dc.date.available2025-01-27T20:43:34Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Diabetes mellitus may lead to functional and structural changes in the brain. Fish oil is a rich source of n-3 essential fatty acids (EFA) such as eicosapentaenoic and docosahexoenoic acids. We examined the neuroprotective effects of fish n-3 EFA in the hippocampus of diabetic rats. Materials and methods: Nineteen adult male rats were divided into three groups. Group I ( control; n=6) was fed a normal rat diet. Group II ( diabetic; n=6) was fed a normal rat diet and streptozotocin (STZ) was administered to induce diabetes mellitus. Group III (n-3 + diabetic; n=7) was fed a normal rat diet and fish n-3 EFA (Marincap (R), 0.4 g/kg/day) for 8 weeks and STZ was administered to induce diabetes mellitus. The levels of malondialdehyde (MDA) and activities of superoxide dismutase ( SOD) and catalase ( CAT) were measured in the left hippocampus after the animals were sacrificed. The right hemisphere was completely blocked. The sections were stained with Cresyl Violet and apoptotic neurons were counted in the hippocampus. Results: The levels of MDA and activities of SOD and CAT increased in diabetic rats compared to control rats. However, the levels of MDA and activities of SOD and CAT decreased in n-3 + diabetic rats compared to diabetic rats. Also, the number of apoptotic neurons increased in diabetic rats compared to control rats and decreased in n-3 + diabetic rats compared to diabetic rats. Conclusions: Fish n-3 EFA reduces oxidative stress and induces apoptotic changes in the hippocampus of STZ-diabetic rats. The addition of fish n-3 EFA to diets may be useful to prevent functional and structural changes to cerebral centers due to diabetes mellitus.
dc.identifier.doi10.1179/147683008X301531
dc.identifier.endpage166
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue4
dc.identifier.pmid18681984
dc.identifier.scopus2-s2.0-50449083475
dc.identifier.scopusqualityQ1
dc.identifier.startpage161
dc.identifier.urihttps://doi.org/10.1179/147683008X301531
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24274
dc.identifier.volume11
dc.identifier.wosWOS:000267975100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNutritional Neuroscience
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantioxidant enzymes
dc.subjectdiabetes mellitus
dc.subjectfish n-3 fatty acids
dc.subjecthippocampus
dc.titleThe neuroprotective effect of fish n-3 fatty acids in the hippocampus of diabetic rats
dc.typeArticle

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