Protective role of heparin in the injury of the liver and kidney on the experimental model of ischemia/reperfusion

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dc.authoridAnkarali, Handan/0000-0002-3613-0523
dc.authoridAkin, Tezcan/0000-0001-8786-6269
dc.contributor.authorYener, Ali Umit
dc.contributor.authorCicek, Mustafa Cuneyt
dc.contributor.authorGenc, Serhat Bahadir
dc.contributor.authorOzkan, Turgut
dc.contributor.authorDogan, Emre
dc.contributor.authorBilgin, Bulent Caglar
dc.contributor.authorAkin, Tezcan
dc.date.accessioned2025-01-27T20:39:03Z
dc.date.available2025-01-27T20:39:03Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Surgery of thoracoabdominal aortic aneurysms (TAAA) is associated with high incidence of serious complications. Ischemia/reperfusion (I/R) injury may be responsible for these complications. We investigated the effect of degree of anticoagulation on remote organ I/R injuries and whether heparin is protective against I/R injury in addition to its anticoagulant properties. Methods: Spraque Dawley rats were used to determine both liver and kidney concentrations of HSP-70, IL-6, MPO in four groups: ischemic control (operation with cross-clamping and intraperitoneal administration of 0.9% saline, n = 7), sham (operation without cross-clamping, n = 7), heparin (ACT level about 200), and high dose heparin (ACT level up to 600). Histological analyses of the organs were performed. Results: Histopathological evaluation of kidney presented significant differences between groups with regards to the cytoplasmic vacuole formation, hemorrhage, tubular cell degeneration and tubular dilatation while heparinized group had best results. The kidney MPO and HSP-70 levels significantly decreased (p < 0.05), but IL-6 level was not significant (p > 0.05) in heparinized group when compared to ischemic control group. No statistically significant intergroup differences were detected in the tissue samples of liver. Immunohistochemical markers of the liver were compared and no statistically significant difference was found among the groups. Conclusion: Heparin is an important anticoagulation agent in TAAA surgical procedures but the use of higher levels of heparin in the present study revealed no beneficial effects. Bleeding complications is much less when heparin is used in the real-world clinical practice as ACT levels of 200.
dc.identifier.doi10.1186/1749-8090-9-35
dc.identifier.issn1749-8090
dc.identifier.pmid24533613
dc.identifier.scopus2-s2.0-84894298433
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/1749-8090-9-35
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23845
dc.identifier.volume9
dc.identifier.wosWOS:000331891100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Cardiothoracic Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHeparin
dc.subjectIschemia
dc.subjectReperfusion
dc.subjectLung
dc.subjectKidney
dc.titleProtective role of heparin in the injury of the liver and kidney on the experimental model of ischemia/reperfusion
dc.typeArticle

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