Synthesis and characterization of 2-hydroxyethylmethacrylate/2-(3-indol-yl)ethylmethacrylamide-based novel hydrogels as drug carrier with in vitro antibacterial properties

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dc.authoridBoran, Gokhan/0000-0002-8871-8433
dc.authoridSelcuk Zorer, Ozlem/0000-0002-6486-8365
dc.contributor.authorIlgin, Pinar
dc.contributor.authorZorer, Ozlem Selcuk
dc.contributor.authorÖzay, Özgür
dc.contributor.authorBoran, Gokhan
dc.date.accessioned2025-01-27T20:51:50Z
dc.date.available2025-01-27T20:51:50Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, a new cationic monomer 2-(3-indol-yl)ethylmethacrylamide (IEMA) derived from tryptamine was synthesized in a single step and characterized by Fourier transform infrared (FTIR), H-1-NMR, and C-13-NMR. Then, one-step preparation of novel poly[2-hydroxyethylmethacrylate-c-2-(3-indol-yl)ethylmethacrylamide], or p(HEMA-c-IEMA), copolymeric hydrogels has been performed successfully with IEMA and 2-hydroxyethylmethacrylate (HEMA) as monomers using free radical aqueous polymerization. The hydrogels were characterized with scanning electron microscopy, FTIR, elemental analysis, thermogravimetric analysis, and texture profile analysis instruments. p(HEMA-c-IEMA) hydrogels were used for swelling, diffusion, drug release, and antibacterial activity studies. The drug-release behavior of the hydrogels was determined as a function of time at 37 degrees C in pH1.2 and 7.2. The swelling and drug-release studies showed that an increased IEMA amount caused a higher increase in swelling and drug-release values. Additionally, zero-order, first-order, and Higuchi equation kinetic models were applied to the drug-release data, and the data fit well in the Higuchi model, and the Peppas power-law model was applied to the release mechanism. Finally, the antibacterial activities of the hydrogels were screened against Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhimurium). (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45550.
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Support Unit [2015-FBE-D222]
dc.description.sponsorshipThe authors are grateful for the financial support of the Van Yuzuncu Yil University Scientific Research Projects Support Unit (project number 2015-FBE-D222).
dc.identifier.doi10.1002/app.45550
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue47
dc.identifier.scopus2-s2.0-85028925934
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.45550
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25541
dc.identifier.volume134
dc.identifier.wosWOS:000409466800026
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Applied Polymer Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcopolymers
dc.subjectdrug delivery systems
dc.subjectkinetics
dc.subjectstimuli-sensitive polymers
dc.titleSynthesis and characterization of 2-hydroxyethylmethacrylate/2-(3-indol-yl)ethylmethacrylamide-based novel hydrogels as drug carrier with in vitro antibacterial properties
dc.typeArticle

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