Possible association between germline methylenetetrahydrofolate reductase gene polymorphisms and psoriasis risk in a Turkish population

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorKilic, S.
dc.contributor.authorOzdemir, O.
dc.contributor.authorSılan, Fatma
dc.contributor.authorIsik, S.
dc.contributor.authorYildiz, O.
dc.contributor.authorKaraagacli, D.
dc.contributor.authorSılan, Coşkun
dc.date.accessioned2025-01-27T20:38:36Z
dc.date.available2025-01-27T20:38:36Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground. Psoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors. There are conflicting results in the literature about the association between psoriasis and the methylenetetrahydrofolate reductase gene (MTHFR), ranging from strong linkage to no association. Aim. To investigate the association between the germline MTHFR polymorphisms C677T and A1298C with psoriasis risk in a Turkish population. Methods. The study enrolled 84 patients with psoriasis and 212 healthy controls (HCs) without any history of psoriasis. DNA was extracted from peripheral blood samples of patients and HCs, and real-time PCR was used for genotyping. Results were compared by Pearson chi(2) test and multiple logistic regression models. Results. The frequency of both the MTHFR 677TT and A1298C (homozygous) genotypes was statistically significantly different from HCs. Point mutations were detected in all patients with early-onset psoriasis (before the age of 20 years). The T allele of MTHFR 677 and the C allele of MTHFR 1298 increased psoriasis risk by 12.4-and 17.0-fold, respectively, in patients compared with HCs. Conclusion. A possible association was detected betweengermline MTHFR 677 C>T and 1298 A>C genotypes and psoriasis risk in a Turkish population. These results need to be confirmed in further studies with larger sample sizes.
dc.identifier.doi10.1111/ced.12909
dc.identifier.endpage13
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue1
dc.identifier.pmid28028860
dc.identifier.scopus2-s2.0-85007173709
dc.identifier.scopusqualityQ2
dc.identifier.startpage8
dc.identifier.urihttps://doi.org/10.1111/ced.12909
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23659
dc.identifier.volume42
dc.identifier.wosWOS:000393911200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical and Experimental Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHomocysteine Metabolism
dc.subjectSusceptibility Loci
dc.subjectCommon Mutation
dc.subjectFolate
dc.subjectMethotrexate
dc.subjectToxicity
dc.subjectEfficacy
dc.subjectTherapy
dc.subjectDisease
dc.subjectA1298c
dc.titlePossible association between germline methylenetetrahydrofolate reductase gene polymorphisms and psoriasis risk in a Turkish population
dc.typeArticle

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