THE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE

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dc.contributor.authorCakir, D. U.
dc.contributor.authorMete, N.
dc.date.accessioned2025-01-27T20:34:56Z
dc.date.available2025-01-27T20:34:56Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the study was to investigate the relationship of eNOS (4 intron 27bp) polymorphism in clinically classified patients with coronary artery disease (CAD) in Turkish population PCR and restriction fragment length polymorphism analysis were used to detect the variant of the eNOS gene in 74 patients' with CAD and 20 healthy controls The CAD group was separated into 3 clinical groups depending on angiography criteria and clinical form designation 1st Group Myocardial infarction (MI) (n 20) 2nd Group Unstable Angina Pectoris (UAP) (n 18) 3rd Group Stable Angina Pectoris (SAP) (n 36) When a and b allele frequencies in the CAD and control groups we, e compared no statistically significant difference was found No significant difference was observed in the 4 intron 27 bp variants of the eNOS gene when CAD patients were compared without distinguishing them clinically from the control group When we assessed CAD patients classified according to their clinical form no significant difference was determined in allele frequencies and genotype distribution in the subgroups except for subgroup S4P When we compared SAP patients with the other subgroups and with the control group it was found that there was a significant increase in the ab genotype and the a allele frequency and a decrease in the bb genotype (p < 0 05) In conclusion CAD seemed to develop without any alterations in eNOS (4 intron 27bp) genotype frequency However the 27 bp repeat polymorphism of the eNOS gene in patients with SAP can be considered as SAP which may have a hereditary origin High eNOS gene polymorphism in patients with SAP can be related to the increased risk of possible coronary occurrence in future It was concluded that further studies of the relationship between eNOS gene polymorphism and CAD should take account of the clinical forms of CAD
dc.description.sponsorshipDicle University
dc.description.sponsorshipThis study was supported by the Research Project Coordinators of Dicle University
dc.identifier.doi10.2478/V10133-010-0083-6
dc.identifier.endpage2121
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue4
dc.identifier.scopus2-s2.0-78649779536
dc.identifier.scopusqualityQ3
dc.identifier.startpage2117
dc.identifier.urihttps://doi.org/10.2478/V10133-010-0083-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23518
dc.identifier.volume24
dc.identifier.wosWOS:000284717900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCoronary Artery Disease (CAD)
dc.subjectMyocardial Infarction (MI)
dc.subjectUnstable Angina Pectoris (UAP)
dc.subjectStable Angina Pectoris (SAP)
dc.subjectatherosclerosis
dc.subjectNitric Oxide (NO)
dc.subjecteNOS gene polymorphism
dc.titleTHE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE
dc.typeArticle

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