Evaluation of background DNA damage in a Turkish population measured by means of the cytokinesis-block micronucleus cytome assay

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dc.authoridCAYIR, AKIN/0000-0002-2014-6635
dc.contributor.authorCoskun, Mahmut
dc.contributor.authorCayir, Akin
dc.contributor.authorCoskun, Munevver
dc.contributor.authorTok, Hayal
dc.date.accessioned2025-01-27T20:38:38Z
dc.date.available2025-01-27T20:38:38Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study aimed to determine the background incidence of micronuclei (MN), nucleoplasmic bridges (NPBs), and nuclear buds (NBUDs) in the peripheral blood lymphocytes of a population in the province of Canakkale, Turkey. Seventy-one individuals living under similar socio-economic conditions, not exposed to an X-ray examination during the last six months, receiving no medical treatment and not involved in agricultural activities were evaluated. In addition to genetic end-points, the cytokinesis-block proliferation index (CBPI) was determined. MN and NBUD frequencies gradually increased with age. MN frequencies of the older group were similar to 7 fold higher than those of the younger group. Multiple linear regression analysis showed that apart from age, no significant effects of various confounding factors on MN and NBUD were observed. NPB frequencies were affected by gender. In the present study, no statistically significant effect was found of smoking on the genetic end-points evaluated, which agrees with results from other studies. (C) 2013 Elsevier B.V. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University Research Foundation (BAP) [2009/46]
dc.description.sponsorshipThis study was financially supported by the Canakkale Onsekiz Mart University Research Foundation (BAP) under project number 2009/46.
dc.identifier.doi10.1016/j.mrgentox.2013.03.010
dc.identifier.endpage27
dc.identifier.issn1383-5718
dc.identifier.issn1879-3592
dc.identifier.issue1
dc.identifier.pmid23827779
dc.identifier.scopus2-s2.0-84891507947
dc.identifier.scopusqualityQ3
dc.identifier.startpage23
dc.identifier.urihttps://doi.org/10.1016/j.mrgentox.2013.03.010
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23683
dc.identifier.volume757
dc.identifier.wosWOS:000325954600004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMutation Research-Genetic Toxicology and Environmental Mutagenesis
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBackground DNA damage
dc.subjectCytome assay
dc.subjectMicronucleus
dc.subjectNucleoplasmic bridge
dc.subjectNuclear bud
dc.titleEvaluation of background DNA damage in a Turkish population measured by means of the cytokinesis-block micronucleus cytome assay
dc.typeArticle

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