The expression and prognostic significance of the tumour-associated glycoprotein 72 in the normal, hyperplastic and neoplastic endometrium using immunohistochemical methods

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dc.contributor.authorMizrak, Togla
dc.contributor.authorUysal, Ahmet
dc.contributor.authorTaner, Cuneyt Eftal
dc.contributor.authorBayol, Umit
dc.date.accessioned2025-01-27T20:20:07Z
dc.date.available2025-01-27T20:20:07Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim of the study: Our aim was to investigate the expression and the prognostic significance of tumour-associated glycoprotein 72 (TAG-72), which is an epithelial tumour marker, using immunohistochemical methods in the normal, hyperplastic and neoplastic endometrium. Material and methods: The study group comprised of 47 cases with simple non-atypical hyperplasia and normal endometrium (n = 17), complex non-atypical hyperplasia (n = 10), and endometrial adenocarcinoma (n = 21). The epithelial tumour marker TAG-72 was determined by immunohistochemical methods. The location of TAG-72 in the differential diagnosis and its prognostic value were statistically analyzed. Results: The immunoreactivity of the immunohistochemical dye was evaluated in terms of the pattern, intensity and pattern + intensity. The comparison between the three groups showed that there was a significant difference in terms of pattern (p < 0.001), intensity (p < 0.001) and pattern + intensity (p < 0.001). The marker TAG-72 was not found to be a prognostic marker for endometrial adenocarcinoma. Conclusions: The marker TAG-72 is a reliable parameter and marker for the differentiation of the neoplastic endometrium from the non-neoplastic and hyperplastic endometrium. There is a significant relationship between the increasing age and staining pattern of the TAG-72 expression. Still, TAG-72 does not seem to be an independent prognostic factor for the endometrial carcinoma.
dc.identifier.doi10.5114/pm.2013.36583
dc.identifier.endpage206
dc.identifier.issn1643-8876
dc.identifier.issn2299-0038
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84884472537
dc.identifier.scopusqualityQ2
dc.identifier.startpage202
dc.identifier.urihttps://doi.org/10.5114/pm.2013.36583
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21566
dc.identifier.volume12
dc.identifier.wosWOS:000322559100004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofMenopause Review-Przeglad Menopauzalny
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectTAG-72
dc.subjectprognostic factor
dc.subjectendometrium
dc.titleThe expression and prognostic significance of the tumour-associated glycoprotein 72 in the normal, hyperplastic and neoplastic endometrium using immunohistochemical methods
dc.typeArticle

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