Scintigraphic evaluation of the osteoblastic activity of rabbit tibial defects after HYAFF11 membrane application

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dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.contributor.authorMermerkaya, Musa Ugur
dc.contributor.authorDoral, Mahmut Nedim
dc.contributor.authorKaraaslan, Fatih
dc.contributor.authorHuri, Gazi
dc.contributor.authorKaracavus, Seyhan
dc.contributor.authorKaymaz, Burak
dc.contributor.authorAlkan, Erkan
dc.date.accessioned2025-01-27T20:16:50Z
dc.date.available2025-01-27T20:16:50Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: An unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect (R) (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place. The aim of this study was to compare osteoblastic activity by the use of scintigraphic methods in defective rabbit tibias during early-phase bone healing with or without a hyaluronan-based mesh. Methods: Two groups (A and B) of New Zealand albino rabbits were used; each group included 10 animals. Operations on all rabbits were performed under general anesthesia. We also resected 10-mm bone segments from each animal's tibial diaphysis. After resection, tibias with defects were fixed using Kirschner wires. In group A, no hyaluronan-based mesh was used. In group B, tibial segmental defects were enclosed with a hyaluronan-based mesh. The rabbits were followed up for 4 weeks postoperatively, after which bone scintigraphic studies were performed on each animal to detect and compare osteoblastic activity. Results: The mean count in the fracture side of the hyaluronan-based mesh group was significantly higher compared to that of the group A (p = 0.019). However, there was no significant difference between group B and control rabbits with respect to the mean count on the intact bone side (p = 0.437). The bone defect (fracture)/intact bone mean count ratio was significantly higher in group B compared to group A (p = 0.008). Conclusions: A hyaluronan-based mesh plays a role in promoting osteoblastic activity. Hyalonect r is suitable for restoring tissue continuity whenever the periosteal membrane is structurally impaired or inadequate. Our results demonstrated that, during early-phase bone healing, osteoblastic activity was increased in bone defect sites when a hyaluronan-based mesh was also used. The most important aspect of this study concerns its scintigraphy-based design. This study is the first to use a scintigraphic method to demonstrate the effectiveness of hyaluronic acid-based material for bone healing.
dc.identifier.doi10.1186/s13018-016-0393-y
dc.identifier.issn1749-799X
dc.identifier.pmid27142755
dc.identifier.scopus2-s2.0-85007489728
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13018-016-0393-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21410
dc.identifier.volume11
dc.identifier.wosWOS:000375958200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Orthopaedic Surgery and Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHyaluronan-based mesh
dc.subjectOsteoblastic activity
dc.subjectBone healing
dc.subjectBone scintigraphy
dc.titleScintigraphic evaluation of the osteoblastic activity of rabbit tibial defects after HYAFF11 membrane application
dc.typeArticle

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