Histopathology of ipsilateral and contralateral ovaries and plasma interleukin 6 levels after unilateral ovarian torsion

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dc.contributor.authorKarakoc-Sokmensuer, L.
dc.contributor.authorHacivelioglu, S.
dc.contributor.authorDemir, A.
dc.contributor.authorKoese, M.
dc.contributor.authorKaymaz, F. F.
dc.contributor.authorCakir, D. U.
dc.contributor.authorBozdag, G.
dc.date.accessioned2025-01-27T20:57:51Z
dc.date.available2025-01-27T20:57:51Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The aim of the present study was to evaluate the time-dependent histopathologic changes in both ovaries and to determine the time-dependent levels of plasma interleukin 6 (IL-6) after unilateral ovarian torsion. Materials and Methods: An experimental animal study included 48 female Sprague-Dawley rats which were distributed to six groups: control group (Group 1), sham-operated control group (Group 2), and four unilateral ovarian torsion groups with torsion duration of three, six, 12, and 24 hours (Group 3, 4, 5, and 6, respectively). Histopathologic criteria (follicular degeneration, vascular congestion, hemorrhage, inflammatory cell infiltration, and total tissue damage score) were evaluated in both ovaries, and plasma IL-6 levels were measured. Results: At 24 hours after torsion began, mean total tissue damage score was similar between ovaries that had torsion and contralateral ovaries. Mean plasma IL-6 level did not change during the 24 hours after torsion began (p = 0.584). Conclusions: In addition to ovaries that had torsion, histopathologic abnormalities also occurred in contralateral ovaries. These results suggest that contralateral ovaries are not quiescent after unilateral ovarian torsion. Plasma IL-6 levels did not change significantly during the 24 hours after ovarian torsion began, resulting in a limitation of its diagnostic use in the early course of the disease.
dc.identifier.endpage87
dc.identifier.issn0390-6663
dc.identifier.issue1
dc.identifier.pmid27048023
dc.identifier.scopus2-s2.0-84960925604
dc.identifier.scopusqualityQ4
dc.identifier.startpage82
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26527
dc.identifier.volume43
dc.identifier.wosWOS:000370911900016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImr Press
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute abdominal pain
dc.subjectSurgical emergency
dc.subjectBiomarkers
dc.subjectCytokines
dc.titleHistopathology of ipsilateral and contralateral ovaries and plasma interleukin 6 levels after unilateral ovarian torsion
dc.typeArticle

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