Assessment of The Effect of Thymbra capitata Ethanolic Extract on Galleria mellonella Hemolymph Antioxidant Enzymes

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dc.contributor.authorKaya, Serhat
dc.date.accessioned2025-01-27T18:59:15Z
dc.date.available2025-01-27T18:59:15Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractConehead thyme (Thymbra capitata) is widely distributed in the countries of the Mediterranean region and used due to its medical properties. The antibacterial, antifungal, and strong antioxidant properties of T. capitata are known. The model organism Galleria mellonella is mostly preferred for immunological studies and for the study of human pathogens. The aim of the study was to determine the effect of the ethanolic extract of T. capitata on the antioxidant defense of the hemolymph in G. mellonella larva. Solutions prepared with Phosphate-Buffered Saline (PBS) from the dry matter obtained from ethanolic extract at doses between 2 mg mL-1 and 20 mg mL-1 were injected into G. mellonella larvae. According to our findings, T. capitata extract had no effect on malondialdehyde (MDA) levels. However, it was determined that all doses between 10 to 20 mg mL-1 significantly reduced superoxide dismutase (SOD) and catalase (CAT) activities compared to the control groups. According to the results of our study, high doses of T. capitata extract had negative effects on G. mellonella antioxidant defense. © 2022, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.
dc.identifier.doi10.31594/commagene.1204178
dc.identifier.endpage183
dc.identifier.issn2602-456X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85145458345
dc.identifier.scopusqualityQ4
dc.identifier.startpage178
dc.identifier.trdizinid1225072
dc.identifier.urihttps://doi.org/10.31594/commagene.1204178
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1225072
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13207
dc.identifier.volume6
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherABADER (Adıyaman Bilimsel Arastırmalar Dernegi)
dc.relation.ispartofCommagene Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectcatalase; Malondialdehyde; superoxide dismutase; total protein
dc.titleAssessment of The Effect of Thymbra capitata Ethanolic Extract on Galleria mellonella Hemolymph Antioxidant Enzymes
dc.title.alternativeThymbra capitata Etanolik Ekstraktının Galleria mellonella Hemolenf Antioksidan Enzimleri Üzerine Etkisinin Değerlendirilmesi
dc.typeArticle

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