A note on the history of Hirschsprung's disease, and an over 120 years apology

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dc.contributor.authorCelayir, Ayşenur
dc.contributor.authorÇetiner, Handan
dc.contributor.authorAldırmaz Ağartan, Canan
dc.contributor.authorGünaydın, Reyhan
dc.contributor.authorCelayir, Arın
dc.date.accessioned2026-02-03T12:03:06Z
dc.date.available2026-02-03T12:03:06Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn 1886, Harald Hirschsprung presented what he believed to be a new and rare condition at the Berlin Congress for Children's Diseases. In 1888, still unaware of earlier reports, he published a paper titled Constipation in Newborns as a Consequence of Dilation and Hypertrophy of the Colon, suggesting that the enlargement of the colon was congenital. Although he noted a narrowing of the rectum in his initial case, Hirschsprung attributed this condition to a dilated intestine rather than a narrowed rectum. In fact, F. Ruysch had described a case of over-enlarged colon as early as 1691, and in 1800, D. Battini published another case of severe constipation posthumously. Between 1825 and 1888, around 20 similar cases had been documented in medical literature. K. Tittel was the first person to draw attention to the narrow rectum and the absence or scarcity of ganglion cells in this region in 1901. However, he did not identify this as the exact cause of the disease, This was evident not only in his own article but also in references to his work in other publications. Despite this fact in the literature, the disease is known as Hirschsprung Disease. Given the historical and scientific context, it may be time to reconsider the attribution of K. Tittel's discovery and to recognize the significant contributions of him in understanding of this disease.
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK)
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK).
dc.identifier.doi10.1007/s00383-025-06003-z
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue1
dc.identifier.pmid40445375
dc.identifier.scopus2-s2.0-105006909238
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00383-025-06003-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34970
dc.identifier.volume41
dc.identifier.wosWOS:001499627500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectHirschsprung disease
dc.subjectIdiopathic colon dilatation
dc.subjectHistory of medicine
dc.subjectMedical publications
dc.subjectGanglion cell
dc.subjectK. Tittel
dc.titleA note on the history of Hirschsprung's disease, and an over 120 years apology
dc.typeArticle

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