Sensitive Voltammetric Determination of Niclosamide at a disposable pencil graphite electrode

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dc.authoridDilgin, Yusuf/0000-0002-2980-6871
dc.contributor.authorDede, Eda
dc.contributor.authorSaglam, Ozlem
dc.contributor.authorDilgin, Yusuf
dc.date.accessioned2025-01-27T20:27:20Z
dc.date.available2025-01-27T20:27:20Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNiclosamide (NA), an effective drug against tapeworm infections, was electrochemically studied using a pencil graphite electrode (PGE). A low-cost sensitive and selective procedure was developed for determination of NA by recording differential pulse voltammograms of NA in pH 7.0 Britton-Robinson buffer solution containing 0.1 M KCl and 30% DMF at the PGE. The PGE displayed very good electrochemical behavior with significant enhancement of the peak current compared to a glassy carbon electrode. Moreover, results obtained from the differential pulse voltammograms show that PGE offers a disposable, low cost, selective and sensitive electrochemical sensor for determination of NA. Under experimental conditions, the PGE had a linear response range from 0.05 mu M to 10 mu M NA with a detection limit of 0.015 mu M (based on 3(sb)). A relative standard deviation of 0.57% was obtained for five successive determinations of 5 mu M NA, which indicate acceptable repeatability. This voltammetric method was successfully applied to the direct determination of NA in tablets. No interference from the tablet excipients was encountered. (C) 2014 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.electacta.2014.01.153
dc.identifier.endpage26
dc.identifier.issn0013-4686
dc.identifier.issn1873-3859
dc.identifier.scopus2-s2.0-84897723961
dc.identifier.scopusqualityQ1
dc.identifier.startpage20
dc.identifier.urihttps://doi.org/10.1016/j.electacta.2014.01.153
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22662
dc.identifier.volume127
dc.identifier.wosWOS:000336009900003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofElectrochimica Acta
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNiclosamide
dc.subjectPencil graphite electrode
dc.subjectDifferential pulse voltammetry
dc.subjectCyclic voltammetry
dc.titleSensitive Voltammetric Determination of Niclosamide at a disposable pencil graphite electrode
dc.typeArticle

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