Metabolic syndrome and vaspin in patients with bipolar disorder

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dc.authoridCaliskan, Ali Metehan/0000-0002-7347-7200
dc.authoridSahin, Basak/0000-0002-5943-4087
dc.contributor.authorErtekin, Hulya
dc.contributor.authorSahin, Basak
dc.contributor.authorCaliskan, Ali Metehan
dc.contributor.authorInanli, Ikbal
dc.contributor.authorErtekin, Yusuf Haydar
dc.date.accessioned2025-01-27T20:49:45Z
dc.date.available2025-01-27T20:49:45Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMetabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research and Projects Coordination Unit [TSA-2015-561]
dc.description.sponsorshipThis study was financed by Canakkale Onsekiz Mart University Scientific Research and Projects Coordination Unit (Contract No: TSA-2015-561).
dc.identifier.doi10.1016/j.kjms.2018.04.003
dc.identifier.endpage528
dc.identifier.issn1607-551X
dc.identifier.issue9
dc.identifier.pmid30173782
dc.identifier.scopus2-s2.0-85046126692
dc.identifier.scopusqualityQ1
dc.identifier.startpage522
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2018.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25299
dc.identifier.volume34
dc.identifier.wosWOS:000443292200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofKaohsiung Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAdipokines
dc.subjectBipolar disorder
dc.subjectMetabolic syndrome
dc.subjectVaspin
dc.titleMetabolic syndrome and vaspin in patients with bipolar disorder
dc.typeArticle

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