The relationship between visfatin, liver inflammation, and acute phase reactants in chronic viral hepatitis B

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dc.authoridyuksel, enver/0000-0003-0302-932X
dc.contributor.authorYuksel, Enver
dc.contributor.authorAkbal, Erdem
dc.contributor.authorKocak, Erdem
dc.contributor.authorAkyurek, Omer
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorEkiz, Fuat
dc.contributor.authorYilmaz, Baris
dc.date.accessioned2025-01-27T20:25:02Z
dc.date.available2025-01-27T20:25:02Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChronic viral hepatitis B (CHB) is an important cause of morbidity and mortality. Adipokine stimulation might play an important role in the pathogenesis of chronic inflammation. The aim of this study was to evaluate serum visfatin concentrations and the relationship between visfatin, fibrosis, liver inflammation, and acute phase reactants in CHB patients. The sampling universe of the study consisted of 41 CHB patients and 25 healthy controls. All patients had positive hepatitis B surface antigen (Hepatitis e antigen (HBeAg) positive n: 7, n: 34 HBeAg negative) for at least 6 months and detectable serum HBV DNA. Serum visfatin concentrations were significantly higher in the CHB patients [18.0 +/- 10.9 ng dL(-1)] than in the healthy controls [9.4 +/- 1.6 ng dL(-1)] [P < 0.001]. On the other hand, fibrinogen and haptoglobin concentrations were significantly lower in CHB patients. A strong negative correlation was observed between serum visfatin concentration, haptoglobin, and fibrinogen levels; however, there was no significant correlation between visfatin, glucose, alanine aminotransferase, aspartate aminotransferase, BMI, Knodell score, fibrosis score, hepatitis B virus DNA, sedimentation, and C-reactive protein. Visfatin concentrations were elevated and visfatin was negatively correlated with haptoglobin and fibrinogen levels in CHB patients.
dc.identifier.doi10.1007/s00508-015-0723-9
dc.identifier.endpage662
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue17-18
dc.identifier.pmid25854905
dc.identifier.scopus2-s2.0-84927544634
dc.identifier.scopusqualityQ1
dc.identifier.startpage658
dc.identifier.urihttps://doi.org/10.1007/s00508-015-0723-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22418
dc.identifier.volume128
dc.identifier.wosWOS:000385060700008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVisfatin
dc.subjectHaptoglobin
dc.subjectFibrinogen
dc.subjectChronic hepatitis B
dc.titleThe relationship between visfatin, liver inflammation, and acute phase reactants in chronic viral hepatitis B
dc.typeArticle

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