Nitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction

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dc.authoridKURT, HASAN ANIL/0000-0001-7292-2248
dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.contributor.authorAlan, Cabir
dc.contributor.authorKurt, Hasan Anil
dc.contributor.authorTopaloglu, Naci
dc.contributor.authorErsay, Ahmet Resit
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorBasturk, Gokhan
dc.date.accessioned2025-01-27T20:49:45Z
dc.date.available2025-01-27T20:49:45Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Our aim is to measure asymmetric dimethyl arginine and nitric oxide levels in rats with induced unilateral acute ureteral obstruction to research the effects on the kidney. Material and Methods: The study included 21 adolescent (average age 6 weeks) Sprague-Dawley male rats weighing between 240-290g divided at random into 3 groups. Group-1: Control group (n= 6): underwent no procedures. Group-2: Sham group ( n= 6): underwent the same procedures as the experimental group without ureter and psoas muscle dissection. Group-3: Group with induced partial unilateral ureteral obstruction (n= 9). All rats were sacrificed after 12 weeks. Superoxide dismutase enzyme activity and nitrite and nitrate salt levels were measured in renal tissue. Plasma nitrite-nitrate and ADMA levels were examined. Results: In the experimental group histopathological changes observed included renal pelvis dilatation, flattened papillae, sclerotic glomerulus and fibrosis. In the experimental group tissue SOD and blood ADMA levels were higher than the control and sham groups (p< 0.05) while tissue NO and plasma NO values were lower than in the sham and control groups (p< 0.05). Conclusion: Oxidative stress and disruption of NO synthesis play an important role in renal function and histopathological changes after obstructive renal disease. To prevent renal complications developing after obstructive nephropathy we believe that a new strategy may be research on reducing ADMA.
dc.identifier.doi10.1590/S1677-5538.IBJU.2015.0030
dc.identifier.endpage620
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue3
dc.identifier.pmid27286129
dc.identifier.scopus2-s2.0-84978116636
dc.identifier.scopusqualityQ2
dc.identifier.startpage614
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2015.0030
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25303
dc.identifier.volume42
dc.identifier.wosWOS:000380066200031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectUreteral Obstruction
dc.subjectNitric Oxide
dc.subjectRats
dc.subjectSuperoxide Dismutase
dc.titleNitric oxide and asymmetric dimethyl arginine (ADMA) levels in an experimental hydronephrotic kidney caused by unilateral partial ureteral obstruction
dc.typeArticle

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