Assessment of release and anticancer effect of innovative pH-responsive and antioxidant-biodegradable hydrogel by using Parthenocissus quinquefolia L. extract as a crosslinker

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dc.authoridOnder, Alper/0000-0002-0775-0053
dc.authoridÖzay, Özgür/0000-0001-6589-9844
dc.authoridComert Onder, Ferah/0000-0002-4037-1979
dc.contributor.authorOnder, Ferah Comert
dc.contributor.authorKalin, Sevil
dc.contributor.authorOnder, Alper
dc.contributor.authorOzay, Hava
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:26:56Z
dc.date.available2025-01-27T20:26:56Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe level of toxicity in cancer treatment with chemotherapy can negatively affect the treatment process. Therefore, targeted drug delivery systems play an important role in reducing treatment-related toxicities. Hydrogels with three-dimensional networks are being investigated as drug delivery systems due to their unique properties such as swelling capacity, biocompatibility, and bioavailability. Poly(2-hydroxyethyl methacrylate-co- methacrylic acid)/PQ (p(HEMA-co-MAA)/PQ) hydrogel was prepared by redox polymerization method using Parthenocissus quinquefolia L. (PQ) plant extract, known for its anticancer, antioxidant, and antimicrobial properties, as a crosslinker. PQ hydrogels were prepared with various monomer and cross-linker ratios. The p(HEMAco-MAA)/PQ10 (1:1) with a highly porous structure exhibited high swelling behavior. The phenolic content of p (HEMA-co-MAA)/PQ10 (1:1) hydrogel which has been determined to have high in vitro biodegradability at pH 6.5, increased with the amount of PQ extract used as crosslinker. The pH-responsive, antioxidant, biodegradable, and highly porous p(HEMA-co-MAA)/PQ10 (1:1) hydrogel showed higher doxorubicin (Dox) release behavior at pH 6.5. The Dox-loaded p(HEMA-co-MAA)/PQ10 (1:1) hydrogel drug carrier showed its anticancer effect on inhibition of colonies and cell proliferation against breast cancer cell lines. Our findings show that the p(HEMAco-MAA)/PQ10 (1:1) hydrogel using the PQ plant extract as a crosslinker will be significant potential in combination and cancer therapy studies.
dc.identifier.doi10.1016/j.jddst.2023.105113
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85175567310
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2023.105113
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22505
dc.identifier.volume90
dc.identifier.wosWOS:001111563000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBreast cancer
dc.subjectParthenocissus quinquefolia L.
dc.subjectDoxorubicin
dc.subjectHydrogel
dc.subjectBiodegradable
dc.subjectAntioxidant
dc.subjectDrug delivery
dc.titleAssessment of release and anticancer effect of innovative pH-responsive and antioxidant-biodegradable hydrogel by using Parthenocissus quinquefolia L. extract as a crosslinker
dc.typeArticle

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