In Vitro Effects of Pantoprazole on Contractile Tone and Contraction Frequency of Rat Pyloric Sphincter

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dc.contributor.authorTas, Sukru
dc.contributor.authorOzer, Ilter
dc.date.accessioned2025-01-27T20:53:52Z
dc.date.available2025-01-27T20:53:52Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe goal of this study to evaluate the possible effects of three different doses of pantoprazole exposure on rat pyloric sphincter contractile tone and contraction frequency in an in vitro experimental study. Following a 60 min equilibration period for stabilization, the contractile response to carbachol was obtained by application of a single dose of carbachol. After the contractions plateaued, pantoprazole concentration-response curves for the experimental group (n= 10) were obtained in a cumulative manner for pantoprazole doses of 5 x 10(-6) mol/L, 5 x 10(-6) mol/L and 1.5 x 10(-4) mol/L, with each dose being held for 15 min. In the control group (n= 10), distilled water was added to the organ bath. Mean percentage of changes in contractile tone and contraction frequency were calculated for each 15 min periods. The contractile tone and contraction frequency decreased in all periods in both groups. Neither contraction tone nor contraction frequency mean percentage of change differed among the periods in the control group. In the experimental group, significant inter-period differences were observed for mean change in contraction tone (period 1 vs. 2, p = 0.013) but not for mean change in contraction frequency (all p > 0.05). It was thought that pantoprazole may relax the pyloric ring by decreasing contractile tone in a dose-dependent manner.
dc.identifier.endpage705
dc.identifier.issn0326-2383
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85015165647
dc.identifier.scopusqualityQ4
dc.identifier.startpage701
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25879
dc.identifier.volume36
dc.identifier.wosWOS:000401271800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherColegio Farmaceuticos Provincia De Buenos Aires
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectContraction
dc.subjectExperimental Study
dc.subjectPantoprazole
dc.subjectPylor
dc.subjectRat
dc.titleIn Vitro Effects of Pantoprazole on Contractile Tone and Contraction Frequency of Rat Pyloric Sphincter
dc.typeArticle

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