Selenium protects cerebral cells by cisplatin induced neurotoxicity

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dc.authoridKaravelioglu, Ergun/0000-0002-6611-1032
dc.authoridKOC, EMINE RABIA/0000-0002-0264-7284
dc.authoridkarademir, mustafa/0000-0002-0734-9040
dc.contributor.authorKaravelioglu, Ergun
dc.contributor.authorBoyaci, Mehmet Gazi
dc.contributor.authorSimsek, Nejdet
dc.contributor.authorSonmez, Mehmet Akif
dc.contributor.authorKoc, Rabia
dc.contributor.authorKarademir, Mustafa
dc.contributor.authorGuven, Mustafa
dc.date.accessioned2025-01-27T20:39:28Z
dc.date.available2025-01-27T20:39:28Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. METHODS: Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time. RESULTS: Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity. CONCLUSION: Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.
dc.identifier.doi10.1590/S0102-865020150060000004
dc.identifier.endpage400
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6
dc.identifier.pmid26108027
dc.identifier.scopus2-s2.0-84933524074
dc.identifier.scopusqualityQ2
dc.identifier.startpage394
dc.identifier.urihttps://doi.org/10.1590/S0102-865020150060000004
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23956
dc.identifier.volume30
dc.identifier.wosWOS:000356828100004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCisplatin
dc.subjectSelenium
dc.subjectNeurotoxicity
dc.subjectRats
dc.titleSelenium protects cerebral cells by cisplatin induced neurotoxicity
dc.typeArticle

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