Anti-colon cancer potential of phenolic compounds from the aerial parts of Centaurea gigantea (Asteraceae)

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dc.authoridKong Thoo Lin, Paul/0000-0002-7090-246X
dc.authoridJaspars, Marcel/0000-0002-2426-6028
dc.authoridNahar, Prof Lutfun/0000-0002-1157-2405
dc.authoridShoeb, Mohammad/0000-0002-9486-2749
dc.contributor.authorShoeb, Mohammad
dc.contributor.authorJaspars, Marcel
dc.contributor.authorMacManns, Stephen M.
dc.contributor.authorCelik, Sezgin
dc.contributor.authorNahar, Lutfun
dc.contributor.authorKong-Thoo-Lin, Paul
dc.contributor.authorSarker, Satyajit D.
dc.date.accessioned2025-01-27T21:00:19Z
dc.date.available2025-01-27T21:00:19Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractReversed-phase HPLC analysis of the methanol extract of the aerial parts of Centaurea gigantea afforded chlorogenic acid and five flavonoids, 2-(4'-hydroxybenzoyl)-isoorientin, orientin, isoorientin, isoquercetrin and cirsiliol. The structures of the these phenolic compounds were established unequivocally by UV, MS, a series of 1D and 2D NMR analyses and by comparison of their spectroscopic data with literature data. The free radical scavenging properties of these compounds were assessed by the DPPH assay, and their toxicity towards brine shrimps, and cytotoxicity towards cancer cells were evaluated, respectively, by the brine shrimp lethality assay and the MTT assay using CaCo-2 colon cancer cell line. Among the compounds, chlorogenic acid exhibited considerable anti-colon cancer activity (IC50=79.0 mu M).
dc.identifier.doi10.1007/s11418-006-0117-4
dc.identifier.endpage169
dc.identifier.issn1340-3443
dc.identifier.issue2
dc.identifier.scopus2-s2.0-49349100601
dc.identifier.scopusqualityQ1
dc.identifier.startpage164
dc.identifier.urihttps://doi.org/10.1007/s11418-006-0117-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26996
dc.identifier.volume61
dc.identifier.wosWOS:000244987000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Tokyo
dc.relation.ispartofJournal of Natural Medicines
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCentaurea gigantea
dc.subjectAsteraceae
dc.subjectCaCo 2
dc.subjectanticancer
dc.subjectMTT assay
dc.subjectNMR
dc.titleAnti-colon cancer potential of phenolic compounds from the aerial parts of Centaurea gigantea (Asteraceae)
dc.typeArticle

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