Effect of the type of cardiopulmonary bypass pump flow on postoperative cognitive function in patients undergoing isolated coronary artery surgery

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dc.contributor.authorOzturk, Selen
dc.contributor.authorSacar, Mustafa
dc.contributor.authorBaltalarli, Ahmet
dc.contributor.authorOzturk, Ibrahim
dc.date.accessioned2025-01-27T20:47:25Z
dc.date.available2025-01-27T20:47:25Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Pulsatile flow, generated by a pump during cardiopulmonary bypass, has been accepted as more physiological in coronary arterybypass grafting surgery (CABG). Therefore, we aimed to investigate the effects of pulsatile and nonpulsatile flow on postoperative cognitive function and to review relationship with the biomarkers S100 beta and neuron-specific enolase (NSE). Methods: Patients who underwent isolated CABG were included this prospective, randomized, double-blind study, which was performed between March 2010 and December 2010. Patients were divided into two groups: pulsatile (Group I, n=20) and nonpulsatile (Group II, n=20) flow. Blood samples were collected 1 day before surgery and in the sixth postoperative hour for the analysis of S100 beta and NSE. In addition, Mini-Mental State Examination (MMSE) was performed during preoperative period and on third postoperative day. Outcomes were determination of effects of pump flow type on cognitive function and relationships with concentrations of S100 beta and NSE. Results: Forty patients were included. No differences were observed between the groups with respect to complications, mortality, S100 beta (Group I: 1.9 +/- 0.2 mu/L; Group II: 2.0 +/- 0.2 mu/L), NSE (Group I: 12.5 +/- 0.8 mu/L; Group II: 12.4 +/- 0.7 mu/L), MMSE scores [Group I: 25 (23-27); Group II: 25 (23-27)], and postoperative cognitive dysfunction (POCD) (p>0.05). No correlation was observed between MMSE scores and concentrations of S100 beta (r=-0.032) and NSE (r=-0.423) (p>0.05). Conclusion: There was no difference between types of pump flow for POCD and no relationship between cognitive dysfunction and S100 beta and NSE concentrations. Pump flow type does not affect NSE concentrations.
dc.identifier.doi10.14744/AnatolJCardiol.2015.6572
dc.identifier.endpage880
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue11
dc.identifier.pmid27163534
dc.identifier.scopus2-s2.0-84995366762
dc.identifier.scopusqualityQ3
dc.identifier.startpage875
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2015.6572
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24899
dc.identifier.volume16
dc.identifier.wosWOS:000392196600017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectpulsatile flow
dc.subjectnonpulsatile flow
dc.subjectS-100 beta protein
dc.subjectneuron-specific enolase
dc.subjectcognitive dysfunction
dc.titleEffect of the type of cardiopulmonary bypass pump flow on postoperative cognitive function in patients undergoing isolated coronary artery surgery
dc.typeArticle

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