The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorAkman, Tarik
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorOzkan, Adile
dc.contributor.authorSen, Halil Murat
dc.contributor.authorOkuyucu, Ali
dc.contributor.authorKalkan, Yildiray
dc.date.accessioned2025-01-27T20:47:31Z
dc.date.available2025-01-27T20:47:31Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four rats were divided equally into three groups. A middle cerebral artery occlusion model was performed in this study where sham and glycyrrhizic acid were administered intraperitoneally following middle cerebral artery occlusion. Group I was evaluated as control. Malondialdehyde (MDA), superoxide dismutase (SOD), and nuclear respiratory factor-1 (NRF1) levels were analyzed biochemically on the right cerebral hemisphere, while ischemic histopathological studies were completed to investigate the anti-oxidant status. Biochemical results showed that SOD and NRF1 levels were significantly increased in the glycyrrhizic acid group compared with the sham group while MDA levels were significantly decreased. On histopathological examination, cerebral edema, vacuolization, degeneration, and destruction of neurons were decreased in the glycyrrhizic acid group compared with the sham group. Cerebral ischemia was attenuated by glycyrrhizic acid administration. These observations indicate that glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress.
dc.identifier.doi10.1007/s10753-015-0133-1
dc.identifier.endpage1588
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4
dc.identifier.pmid25687639
dc.identifier.scopus2-s2.0-84937252149
dc.identifier.scopusqualityQ1
dc.identifier.startpage1581
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0133-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24943
dc.identifier.volume38
dc.identifier.wosWOS:000357666000023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbrain ischemia
dc.subjectglycyrrhizic acid
dc.subjectmiddle cerebral artery
dc.subjectcaspase-3
dc.subjectapoptosis
dc.titleThe Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats
dc.typeArticle

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