Liver Fatty Acid-binding Protein Is A Diagnostic Marker to Detect Liver Injury Due to Chronic Hepatitis C Infection

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dc.contributor.authorAkbal, Erdem
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorKocak, Erdem
dc.contributor.authorCakal, Basak
dc.contributor.authorGunes, Fahri
dc.contributor.authorBasar, Omer
dc.contributor.authorTuna, Yasar
dc.date.accessioned2025-01-27T20:34:51Z
dc.date.available2025-01-27T20:34:51Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and Aims. Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC). Methods. We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method. Results. Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively. Conclusions. Serum L-FABP is used as a new diagnostic marker to detect liver injury. (C) 2013 IMSS. Published by Elsevier Inc.
dc.identifier.doi10.1016/j.arcmed.2012.11.007
dc.identifier.endpage38
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue1
dc.identifier.pmid23291381
dc.identifier.scopus2-s2.0-84873103226
dc.identifier.scopusqualityQ1
dc.identifier.startpage34
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2012.11.007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23493
dc.identifier.volume44
dc.identifier.wosWOS:000315070200006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofArchives of Medical Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectLiver fatty acid-binding protein
dc.subjectChronic hepatitis C
dc.subjectDiagnosis
dc.titleLiver Fatty Acid-binding Protein Is A Diagnostic Marker to Detect Liver Injury Due to Chronic Hepatitis C Infection
dc.typeArticle

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