Lead exposure is a risk for worsening bone mineral density in middle-aged male workers

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dc.contributor.authorAkbal, Ayla
dc.contributor.authorTutkun, Engin
dc.contributor.authorYilmaz, Hinc
dc.date.accessioned2025-01-27T20:47:49Z
dc.date.available2025-01-27T20:47:49Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Lead exposure linked to osteoporosis in women. However, there is no direct evidence whether lead exposure has effects on bone metabolism in middle-aged male subjects. Therefore, the present study investigated the relationship between bone mineral densitometry measurements, bone markers, endocrine hormones and blood lead levels. Material and methods: The present study included lead exposure patients (n: 30) and control subjects (n: 32). We recorded information on patient demographics and risk factors of osteoporosis. Blood lead levels were evaluated using Varian AA 240Z atomic absorption spectrophotometry. Bone mineral density measurements were measured using dual-energy X-ray absorptiometry. Results: Each lumbar T and Z scores in the lead exposure group were lower than the control group. There were no significant differences in femur neck and femur total T and Z scores between two groups. Blood lead levels were also negatively correlated with lumbar 2-4 T score, total lumbar T score, lumbar 2-4 Z score and total lumbar Z score. Urinary hydroxyproline and urinary deoxypyridinoline levels in the lead exposure group were significantly higher compared to controls. Blood lead levels were strong, positively correlated with urinary deoxypyridinoline. Endocrine hormone levels and 1,25-dihydroxy-vitamin D3 levels were comparable between lead exposure and control group. Conclusion: Lead exposure in male workers is an important factor for deterioration in bone mineral density. We should be screening blood lead levels and history of lead exposure in male osteoporosis.
dc.identifier.doi10.3109/13685538.2013.836482
dc.identifier.endpage193
dc.identifier.issn1368-5538
dc.identifier.issn1473-0790
dc.identifier.issue3
dc.identifier.pmid24090225
dc.identifier.scopus2-s2.0-84906345497
dc.identifier.scopusqualityQ2
dc.identifier.startpage189
dc.identifier.urihttps://doi.org/10.3109/13685538.2013.836482
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25055
dc.identifier.volume17
dc.identifier.wosWOS:000340832700011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofAging Male
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBone formation
dc.subjectbone mineral density
dc.subjectbone resorption
dc.subjectendocrine factors
dc.subjectlead exposure
dc.titleLead exposure is a risk for worsening bone mineral density in middle-aged male workers
dc.typeArticle

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